Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation
Abstract Background Acute post-cataract endophthalmitis (APE) is a rare complication potentially causing irreversible visual loss. A 10-year study of APE was conducted to determine its incidence, microbiological spectra and antibiotic resistance profile of APE-related pathogens at a major tertiary r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-021-00280-1 |
| _version_ | 1818878230729326592 |
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| author | Juliana Mika Kato Tatiana Tanaka Luiza Manhezi Shin de Oliveira Maura Salaroli de Oliveira Flavia Rossi Mauro Goldbaum Sergio Luis Gianotti Pimentel João Nóbrega de Almeida Junior Joyce Hisae Yamamoto |
| author_facet | Juliana Mika Kato Tatiana Tanaka Luiza Manhezi Shin de Oliveira Maura Salaroli de Oliveira Flavia Rossi Mauro Goldbaum Sergio Luis Gianotti Pimentel João Nóbrega de Almeida Junior Joyce Hisae Yamamoto |
| author_sort | Juliana Mika Kato |
| collection | DOAJ |
| description | Abstract Background Acute post-cataract endophthalmitis (APE) is a rare complication potentially causing irreversible visual loss. A 10-year study of APE was conducted to determine its incidence, microbiological spectra and antibiotic resistance profile of APE-related pathogens at a major tertiary referral center in Brazil. Methods APE cases reported between January 2010 and December 2019 were included. Phacoemulsification and extracapsular cataract techniques were eligible; combined procedures, traumatic and congenital cataract were excluded. Vitreous samples were cultured and antimicrobial resistance was compared for the periods of 2010–2014 and 2015–2019. The results were analyzed with Fisher’s exact test. Results Our sample consisted of 40,491 cataract surgeries and 51 (0.126%) APE cases. Culture was positive in 35 cases (71.4%), of which 31 (88.6%) Gram-positive, 3 (8.6%) Gram-negative, and 1 (2.9%) fungal. The most frequently isolated organism was Staphylococcus epidermidis (n = 17/35, 48.6%), followed by Staphylococcus aureus (n = 4/35, 11.4%). From 2010–2014 to 2015–2019, antimicrobial resistance increased against moxifloxacin (11.1–54.5%, p = 0.07), ciprofloxacin (54.5–72.7%, p = 0.659) and oxacillin (66.7–93.3%, p = 0.13). Conclusions The observed incidence and microbial spectra were compatible with previous studies. A trend towards growing moxifloxacin and ciprofloxacin resistance was observed. Surveillance remains crucial to prevent treatment failure from antimicrobial resistance. |
| first_indexed | 2024-12-19T14:10:53Z |
| format | Article |
| id | doaj.art-8bb99f6405654ae6928e6ccb43edb54d |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-19T14:10:53Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-8bb99f6405654ae6928e6ccb43edb54d2022-12-21T20:18:08ZengBMCInternational Journal of Retina and Vitreous2056-99202021-02-01711610.1186/s40942-021-00280-1Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluationJuliana Mika Kato0Tatiana Tanaka1Luiza Manhezi Shin de Oliveira2Maura Salaroli de Oliveira3Flavia Rossi4Mauro Goldbaum5Sergio Luis Gianotti Pimentel6João Nóbrega de Almeida Junior7Joyce Hisae Yamamoto8Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDepartment of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDepartment of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDivision of Infectious and Parasitic Diseases, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloCentral Laboratory Division-LIM03, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDepartment of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDepartment of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloCentral Laboratory Division-LIM03, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloDepartment of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloAbstract Background Acute post-cataract endophthalmitis (APE) is a rare complication potentially causing irreversible visual loss. A 10-year study of APE was conducted to determine its incidence, microbiological spectra and antibiotic resistance profile of APE-related pathogens at a major tertiary referral center in Brazil. Methods APE cases reported between January 2010 and December 2019 were included. Phacoemulsification and extracapsular cataract techniques were eligible; combined procedures, traumatic and congenital cataract were excluded. Vitreous samples were cultured and antimicrobial resistance was compared for the periods of 2010–2014 and 2015–2019. The results were analyzed with Fisher’s exact test. Results Our sample consisted of 40,491 cataract surgeries and 51 (0.126%) APE cases. Culture was positive in 35 cases (71.4%), of which 31 (88.6%) Gram-positive, 3 (8.6%) Gram-negative, and 1 (2.9%) fungal. The most frequently isolated organism was Staphylococcus epidermidis (n = 17/35, 48.6%), followed by Staphylococcus aureus (n = 4/35, 11.4%). From 2010–2014 to 2015–2019, antimicrobial resistance increased against moxifloxacin (11.1–54.5%, p = 0.07), ciprofloxacin (54.5–72.7%, p = 0.659) and oxacillin (66.7–93.3%, p = 0.13). Conclusions The observed incidence and microbial spectra were compatible with previous studies. A trend towards growing moxifloxacin and ciprofloxacin resistance was observed. Surveillance remains crucial to prevent treatment failure from antimicrobial resistance.https://doi.org/10.1186/s40942-021-00280-1EndophthalmitisCataract surgeryAntibiotic resistance |
| spellingShingle | Juliana Mika Kato Tatiana Tanaka Luiza Manhezi Shin de Oliveira Maura Salaroli de Oliveira Flavia Rossi Mauro Goldbaum Sergio Luis Gianotti Pimentel João Nóbrega de Almeida Junior Joyce Hisae Yamamoto Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation International Journal of Retina and Vitreous Endophthalmitis Cataract surgery Antibiotic resistance |
| title | Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation |
| title_full | Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation |
| title_fullStr | Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation |
| title_full_unstemmed | Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation |
| title_short | Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation |
| title_sort | surveillance of post cataract endophthalmitis at a tertiary referral center a 10 year critical evaluation |
| topic | Endophthalmitis Cataract surgery Antibiotic resistance |
| url | https://doi.org/10.1186/s40942-021-00280-1 |
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