Genetic Modeling of the Neurodegenerative Disease Spinocerebellar Ataxia Type 1 in Zebrafish

Genetic Modeling of the Neurodegenerative Disease Spinocerebellar Ataxia Type 1 in Zebrafish

Dominant spinocerebellar ataxias (SCAs) are progredient neurodegenerative diseases commonly affecting the survival of Purkinje cells (PCs) in the human cerebellum. Spinocerebellar ataxia type 1 (SCA1) is caused by the mutated <i>ataxin1</i> (<i>Atx1</i>) gene product, in whic...

Full description

Bibliographic Details
Main Authors: Mohamed A. Elsaey, Kazuhiko Namikawa, Reinhard W. Köster
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
spinocerebellar ataxia type 1
cerebellum
polyglutamine disease
neurodegeneration
Purkinje cells
bioimaging
Online Access:https://www.mdpi.com/1422-0067/22/14/7351

Internet

https://www.mdpi.com/1422-0067/22/14/7351

Similar Items