EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS
The purpose of the study was to analyze the antitumor effects of the extract of mycelium from Duddingtonia flagrans (strain F-882) on xenografts of human C33a cervical cancer cells.Material and Methods. To evaluate the antitumor effect, we used the absolute values of xenograft volumes and calculated...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2020-12-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1644 |
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| author | O. I. Solovieva E. L. Zavjalov T. V. Teplyakova L. R. Lebedev i A. Razumov |
| author_facet | O. I. Solovieva E. L. Zavjalov T. V. Teplyakova L. R. Lebedev i A. Razumov |
| author_sort | O. I. Solovieva |
| collection | DOAJ |
| description | The purpose of the study was to analyze the antitumor effects of the extract of mycelium from Duddingtonia flagrans (strain F-882) on xenografts of human C33a cervical cancer cells.Material and Methods. To evaluate the antitumor effect, we used the absolute values of xenograft volumes and calculated the tumor growth inhibition and the index of tumor growth.Results. At the first stage of the experiment, a 4-week subcutaneous injection of the water extract of F-882 resulted in an almost twofold slowdown in xenograft growth, with the tumor growth inhibition value of 50.6 %. In the second stage of the experiment, a 2.5-week subcutaneous injection followed by a 1.5-week intratumoral injection of F-882 also caused the tumor growth inhibition. After completing F-882 injections, the effect of tumor growth inhibition continued for 2.5 weeks and the tumor growth inhibition value was 58.7 %.Conclusion. The mycelium extract F-882 was shown to have an antitumor effect on subcutaneous xenografts of human C33a cervical carcinoma cells. |
| first_indexed | 2024-04-10T01:52:21Z |
| format | Article |
| id | doaj.art-8bba84ffafba45c396bb26d4f3e1555f |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:21Z |
| publishDate | 2020-12-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-8bba84ffafba45c396bb26d4f3e1555f2023-03-13T09:05:54ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682020-12-01196939810.21294/1814-4861-2020-19-6-93-98809EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLSO. I. Solovieva0E. L. Zavjalov1T. V. Teplyakova2L. R. Lebedev3i A. Razumov4ФГБУН ФИЦ «Институт цитологии и генетики» СО РАНФГБУН ФИЦ «Институт цитологии и генетики» СО РАНГосударственный научный центр вирусологии и биотехнологии «Вектор» РоспотребнадзораГосударственный научный центр вирусологии и биотехнологии «Вектор» РоспотребнадзораФГБУН ФИЦ «Институт цитологии и генетики» СО РАН; Государственный научный центр вирусологии и биотехнологии «Вектор» РоспотребнадзораThe purpose of the study was to analyze the antitumor effects of the extract of mycelium from Duddingtonia flagrans (strain F-882) on xenografts of human C33a cervical cancer cells.Material and Methods. To evaluate the antitumor effect, we used the absolute values of xenograft volumes and calculated the tumor growth inhibition and the index of tumor growth.Results. At the first stage of the experiment, a 4-week subcutaneous injection of the water extract of F-882 resulted in an almost twofold slowdown in xenograft growth, with the tumor growth inhibition value of 50.6 %. In the second stage of the experiment, a 2.5-week subcutaneous injection followed by a 1.5-week intratumoral injection of F-882 also caused the tumor growth inhibition. After completing F-882 injections, the effect of tumor growth inhibition continued for 2.5 weeks and the tumor growth inhibition value was 58.7 %.Conclusion. The mycelium extract F-882 was shown to have an antitumor effect on subcutaneous xenografts of human C33a cervical carcinoma cells.https://www.siboncoj.ru/jour/article/view/1644duddingtonia flagransхищные грибыc33aкарцинома шейки маткизлокачественные новообразования. |
| spellingShingle | O. I. Solovieva E. L. Zavjalov T. V. Teplyakova L. R. Lebedev i A. Razumov EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS Сибирский онкологический журнал duddingtonia flagrans хищные грибы c33a карцинома шейки матки злокачественные новообразования. |
| title | EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS |
| title_full | EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS |
| title_fullStr | EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS |
| title_full_unstemmed | EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS |
| title_short | EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS |
| title_sort | effect of the mycelium extract from duddingtonia flagrans fungus on subcutaneous xenograft of human c33a cervical carcinoma cells |
| topic | duddingtonia flagrans хищные грибы c33a карцинома шейки матки злокачественные новообразования. |
| url | https://www.siboncoj.ru/jour/article/view/1644 |
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