Reduced mitochondrial pyruvate carrier expression in hearts with heart failure and reduced ejection fraction patients: ischemic vs. non-ischemic origin

Reduced mitochondrial pyruvate carrier expression in hearts with heart failure and reduced ejection fraction patients: ischemic vs. non-ischemic origin

Introduction and objectivesMitochondrial pyruvate carrier (MPC) mediates the entry of pyruvate into mitochondria, determining whether pyruvate is incorporated into the Krebs cycle or metabolized in the cytosol. In heart failure (HF), a large amount of pyruvate is metabolized to lactate in the cytoso...

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Bibliographic Details
Main Authors: Paula Lopez-Vazquez, Mariana Fernandez-Caggiano, Eduardo Barge-Caballero, Gonzalo Barge-Caballero, David Couto-Mallon, Zulaika Grille-Cancela, Paula Blanco-Canosa, Maria J. Paniagua-Martin, Daniel Enriquez-Vazquez, Jose M. Vazquez-Rodriguez, Nieves Domenech, Maria G. Crespo-Leiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
mitochondria
mitochondrial pyruvate carrier
heart failure
ischemic heart
idiopathic dilated cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1349417/full

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