Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma
The G105G SNP (rs11554137) in the IDH1 gene is observed in about 10–15% of patients with a diffuse glioma. Data regarding its impact on gliomas are poor and partially conflicting, possibly due to the evolving classification of CNS tumors. The aim of this study was to investigate the G105G SNP progno...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1439 |
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| author | Ayoub Saaid Matteo Monticelli Alessia Andrea Ricci Giulia Orlando Cristina Botta Pietro Zeppa Andrea Bianconi Simona Osella-Abate Francesco Bruno Alessia Pellerino Roberta Rudà Paola Cassoni Diego Garbossa Fabio Cofano Luca Bertero |
| author_facet | Ayoub Saaid Matteo Monticelli Alessia Andrea Ricci Giulia Orlando Cristina Botta Pietro Zeppa Andrea Bianconi Simona Osella-Abate Francesco Bruno Alessia Pellerino Roberta Rudà Paola Cassoni Diego Garbossa Fabio Cofano Luca Bertero |
| author_sort | Ayoub Saaid |
| collection | DOAJ |
| description | The G105G SNP (rs11554137) in the IDH1 gene is observed in about 10–15% of patients with a diffuse glioma. Data regarding its impact on gliomas are poor and partially conflicting, possibly due to the evolving classification of CNS tumors. The aim of this study was to investigate the G105G SNP prognostic significance in a homogenous cohort of IDH-wildtype glioblastomas, in agreement with the 2021 WHO classification. The study analyzed 211 patients by collecting several clinico-pathological and molecular characteristics, including the age, lesion localization, number of involved lobes, type of surgical treatment, disease outcome and MGMT promoter methylation status. PFS and DSS curves were plotted according to the Kaplan–Meier method and statistical analyses were performed using parametric and non-parametric tests. A total of 32 patients out of 211 (15.2%) were found to be G105G SNP carriers. No significant impact of the IDH1 G105G SNP on patients’ outcomes was observed in terms of PFS and DSS, while MGMT promoter methylation and gross total resection resulted as key prognostic factors in our cohort as expected. No prognostic impact of the IDH1 G105G SNP was detected in this strict cohort of IDH-wildtype glioblastomas. Analysis of larger cohorts is warranted to address the sample size limitations. |
| first_indexed | 2024-03-09T09:56:28Z |
| format | Article |
| id | doaj.art-8bbe8a873c5945a5b44d154b9ce3c0d2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T09:56:28Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-8bbe8a873c5945a5b44d154b9ce3c0d22023-12-01T23:44:24ZengMDPI AGGenes2073-44252022-08-01138143910.3390/genes13081439Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype GlioblastomaAyoub Saaid0Matteo Monticelli1Alessia Andrea Ricci2Giulia Orlando3Cristina Botta4Pietro Zeppa5Andrea Bianconi6Simona Osella-Abate7Francesco Bruno8Alessia Pellerino9Roberta Rudà10Paola Cassoni11Diego Garbossa12Fabio Cofano13Luca Bertero14Neurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyNeurosurgery Unit, Department of Neuroscience and Rehabilitation, University of Ferrara, 44100 Ferrara, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Oncology, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyNeuro-Oncology Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyNeuro-Oncology Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyNeuro-Oncology Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, 10126 Turin, ItalyPathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, ItalyThe G105G SNP (rs11554137) in the IDH1 gene is observed in about 10–15% of patients with a diffuse glioma. Data regarding its impact on gliomas are poor and partially conflicting, possibly due to the evolving classification of CNS tumors. The aim of this study was to investigate the G105G SNP prognostic significance in a homogenous cohort of IDH-wildtype glioblastomas, in agreement with the 2021 WHO classification. The study analyzed 211 patients by collecting several clinico-pathological and molecular characteristics, including the age, lesion localization, number of involved lobes, type of surgical treatment, disease outcome and MGMT promoter methylation status. PFS and DSS curves were plotted according to the Kaplan–Meier method and statistical analyses were performed using parametric and non-parametric tests. A total of 32 patients out of 211 (15.2%) were found to be G105G SNP carriers. No significant impact of the IDH1 G105G SNP on patients’ outcomes was observed in terms of PFS and DSS, while MGMT promoter methylation and gross total resection resulted as key prognostic factors in our cohort as expected. No prognostic impact of the IDH1 G105G SNP was detected in this strict cohort of IDH-wildtype glioblastomas. Analysis of larger cohorts is warranted to address the sample size limitations.https://www.mdpi.com/2073-4425/13/8/1439IDH1glioblastomars11554137SNPprognosis |
| spellingShingle | Ayoub Saaid Matteo Monticelli Alessia Andrea Ricci Giulia Orlando Cristina Botta Pietro Zeppa Andrea Bianconi Simona Osella-Abate Francesco Bruno Alessia Pellerino Roberta Rudà Paola Cassoni Diego Garbossa Fabio Cofano Luca Bertero Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma Genes IDH1 glioblastoma rs11554137 SNP prognosis |
| title | Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma |
| title_full | Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma |
| title_fullStr | Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma |
| title_full_unstemmed | Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma |
| title_short | Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma |
| title_sort | prognostic analysis of the idh1 g105g rs11554137 snp in idh wildtype glioblastoma |
| topic | IDH1 glioblastoma rs11554137 SNP prognosis |
| url | https://www.mdpi.com/2073-4425/13/8/1439 |
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