Factors Affecting Nodal Status in Breast Cancer
Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evalu...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2020-07-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_92262_04c2f90ab42fd684e7610c88af8e6fc3.pdf |
| _version_ | 1818750483310837760 |
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| author | Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed |
| author_facet | Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed |
| author_sort | Diaa Aboelata |
| collection | DOAJ |
| description | Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evaluation of pre- and post-operative factors related to nodal status in breast cancer. Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra- and post-surgical complications and factors associated with positive nodal status were documented. Results: The most significant factors associated with high positive nodal status were age (patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years (37.68±35.23 vs 17.66±19.45 respectively), obesity (30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively)., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology. Conclusion: Nodal status affected by pre- and post-surgery factors (e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor). Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy. |
| first_indexed | 2024-12-18T04:20:23Z |
| format | Article |
| id | doaj.art-8bbeaacc605342e2bcacdf45b42c27d4 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-12-18T04:20:23Z |
| publishDate | 2020-07-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-8bbeaacc605342e2bcacdf45b42c27d42022-12-21T21:21:14ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802020-07-012353554110.21608/ijma.2020.24500.110592262Factors Affecting Nodal Status in Breast CancerDiaa Aboelata0Amr Sarhan1Mohammed Abo Mira2Sami Mohammed3Department of General Surgery, Tanta Cancer Center, Ministry of Health, Egypt.Department of General surgery, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of General Surgery, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt.Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evaluation of pre- and post-operative factors related to nodal status in breast cancer. Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra- and post-surgical complications and factors associated with positive nodal status were documented. Results: The most significant factors associated with high positive nodal status were age (patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years (37.68±35.23 vs 17.66±19.45 respectively), obesity (30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively)., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology. Conclusion: Nodal status affected by pre- and post-surgery factors (e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor). Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy.https://ijma.journals.ekb.eg/article_92262_04c2f90ab42fd684e7610c88af8e6fc3.pdfaxillary evacuationbreast cancerlymph nodesadjuvant therapyprognosis |
| spellingShingle | Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed Factors Affecting Nodal Status in Breast Cancer International Journal of Medical Arts axillary evacuation breast cancer lymph nodes adjuvant therapy prognosis |
| title | Factors Affecting Nodal Status in Breast Cancer |
| title_full | Factors Affecting Nodal Status in Breast Cancer |
| title_fullStr | Factors Affecting Nodal Status in Breast Cancer |
| title_full_unstemmed | Factors Affecting Nodal Status in Breast Cancer |
| title_short | Factors Affecting Nodal Status in Breast Cancer |
| title_sort | factors affecting nodal status in breast cancer |
| topic | axillary evacuation breast cancer lymph nodes adjuvant therapy prognosis |
| url | https://ijma.journals.ekb.eg/article_92262_04c2f90ab42fd684e7610c88af8e6fc3.pdf |
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