The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub>
<p>Abstract</p> <p>Although it is known that nano-TiO<sub>2</sub>or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO<sub>2</sub>(5 nm) was injected into the abdo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2009-01-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/s11671-009-9393-8 |
| _version_ | 1797763021716586496 |
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| author | Ma Linglan Zhao Jinfang Wang Jue Liu Jie Duan Yanmei Liu Huiting Li Na Yan Jingying Ruan Jie Wang Han Hong Fashui |
| author_facet | Ma Linglan Zhao Jinfang Wang Jue Liu Jie Duan Yanmei Liu Huiting Li Na Yan Jingying Ruan Jie Wang Han Hong Fashui |
| author_sort | Ma Linglan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Although it is known that nano-TiO<sub>2</sub>or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO<sub>2</sub>(5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by higher doses nano-anatase TiO<sub>2</sub>. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO<sub>2</sub>can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-κB, macrophage migration inhibitory factor, tumor necrosis factor-α, interleukin-6, interleukin-1β, cross-reaction protein, interleukin-4, and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nano-anatase TiO<sub>2</sub>-induced liver toxicity.</p> |
| first_indexed | 2024-03-12T19:36:36Z |
| format | Article |
| id | doaj.art-8bc0000718de4139b9ca0bcd8d66962e |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T19:36:36Z |
| publishDate | 2009-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-8bc0000718de4139b9ca0bcd8d66962e2023-08-02T04:10:52ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2009-01-0141112751285The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub>Ma LinglanZhao JinfangWang JueLiu JieDuan YanmeiLiu HuitingLi NaYan JingyingRuan JieWang HanHong Fashui<p>Abstract</p> <p>Although it is known that nano-TiO<sub>2</sub>or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO<sub>2</sub>(5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by higher doses nano-anatase TiO<sub>2</sub>. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO<sub>2</sub>can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-κB, macrophage migration inhibitory factor, tumor necrosis factor-α, interleukin-6, interleukin-1β, cross-reaction protein, interleukin-4, and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nano-anatase TiO<sub>2</sub>-induced liver toxicity.</p>http://dx.doi.org/10.1007/s11671-009-9393-8MiceNano-anatase TiO<sub>2</sub>LiverInflammatory cytokinesHistopathological changes |
| spellingShingle | Ma Linglan Zhao Jinfang Wang Jue Liu Jie Duan Yanmei Liu Huiting Li Na Yan Jingying Ruan Jie Wang Han Hong Fashui The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> Nanoscale Research Letters Mice Nano-anatase TiO<sub>2</sub> Liver Inflammatory cytokines Histopathological changes |
| title | The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> |
| title_full | The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> |
| title_fullStr | The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> |
| title_full_unstemmed | The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> |
| title_short | The Acute Liver Injury in Mice Caused by Nano-Anatase TiO<sub>2</sub> |
| title_sort | acute liver injury in mice caused by nano anatase tio sub 2 sub |
| topic | Mice Nano-anatase TiO<sub>2</sub> Liver Inflammatory cytokines Histopathological changes |
| url | http://dx.doi.org/10.1007/s11671-009-9393-8 |
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