Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia
Hitherto, no data describing the heterogeneity of genetic profiles and risk stratifications of adult acute myeloid leukaemia (AML) in Southeast Asia are reported. This study assessed genetic profiles, Moorman’s hierarchical classification, and ELN 2017-based risk stratifications in relation to age,...
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/258 |
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| author | Angeli Ambayya Anthony V. Moorman Jameela Sathar Jeyanthy Eswaran Sarina Sulong Rosline Hassan |
| author_facet | Angeli Ambayya Anthony V. Moorman Jameela Sathar Jeyanthy Eswaran Sarina Sulong Rosline Hassan |
| author_sort | Angeli Ambayya |
| collection | DOAJ |
| description | Hitherto, no data describing the heterogeneity of genetic profiles and risk stratifications of adult acute myeloid leukaemia (AML) in Southeast Asia are reported. This study assessed genetic profiles, Moorman’s hierarchical classification, and ELN 2017-based risk stratifications in relation to age, gender, and ethnicity in Malaysian adult AML patients. A total of 854 AML patients: male (52%), female (48%) were recruited comprising three main ethnic groups: Malays (59%), Chinese (32%) and Indians (8%). Of 307 patients with abnormal karyotypes: 36% exhibited translocations; 10% deletions and 5% trisomies. The commonest genotype was FLT3-ITD-NPM1wt (276/414; 66.7%). ELN 2017 risk stratification was performed on 494 patients, and 41% were classified as favourable, 39% as intermediate and 20% as adverse groups. More females (47%) were in the favourable risk group compared to males (37%), whereas adverse risk was higher in patients above 60 (24%) of age compared to below 60 (18%) patients. We observed heterogeneity in the distribution of genetic profiles and risk stratifications between the age groups and gender, but not among the ethnic groups. Our study elucidated the diversity of adult AML genetic profiles between Southeast Asians and other regions worldwide. |
| first_indexed | 2024-03-10T03:39:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:39:44Z |
| publishDate | 2021-12-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8bc076769293404b91baad1de19fe42d2023-11-23T11:37:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123125810.3390/ijms23010258Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from MalaysiaAngeli Ambayya0Anthony V. Moorman1Jameela Sathar2Jeyanthy Eswaran3Sarina Sulong4Rosline Hassan5School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 15159, Kelantan, MalaysiaTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKClinical Haematology Referral Laboratory, Haematology Department, Hospital Ampang, Ampang 68000, Selangor, MalaysiaTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKSchool of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 15159, Kelantan, MalaysiaSchool of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 15159, Kelantan, MalaysiaHitherto, no data describing the heterogeneity of genetic profiles and risk stratifications of adult acute myeloid leukaemia (AML) in Southeast Asia are reported. This study assessed genetic profiles, Moorman’s hierarchical classification, and ELN 2017-based risk stratifications in relation to age, gender, and ethnicity in Malaysian adult AML patients. A total of 854 AML patients: male (52%), female (48%) were recruited comprising three main ethnic groups: Malays (59%), Chinese (32%) and Indians (8%). Of 307 patients with abnormal karyotypes: 36% exhibited translocations; 10% deletions and 5% trisomies. The commonest genotype was FLT3-ITD-NPM1wt (276/414; 66.7%). ELN 2017 risk stratification was performed on 494 patients, and 41% were classified as favourable, 39% as intermediate and 20% as adverse groups. More females (47%) were in the favourable risk group compared to males (37%), whereas adverse risk was higher in patients above 60 (24%) of age compared to below 60 (18%) patients. We observed heterogeneity in the distribution of genetic profiles and risk stratifications between the age groups and gender, but not among the ethnic groups. Our study elucidated the diversity of adult AML genetic profiles between Southeast Asians and other regions worldwide.https://www.mdpi.com/1422-0067/23/1/258cytogenetickaryotypeacute myeloid leukaemiageneticsELN 2017 |
| spellingShingle | Angeli Ambayya Anthony V. Moorman Jameela Sathar Jeyanthy Eswaran Sarina Sulong Rosline Hassan Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia International Journal of Molecular Sciences cytogenetic karyotype acute myeloid leukaemia genetics ELN 2017 |
| title | Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia |
| title_full | Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia |
| title_fullStr | Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia |
| title_full_unstemmed | Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia |
| title_short | Genetic Profiles and Risk Stratification in Adult De Novo Acute Myeloid Leukaemia in Relation to Age, Gender, and Ethnicity: A Study from Malaysia |
| title_sort | genetic profiles and risk stratification in adult de novo acute myeloid leukaemia in relation to age gender and ethnicity a study from malaysia |
| topic | cytogenetic karyotype acute myeloid leukaemia genetics ELN 2017 |
| url | https://www.mdpi.com/1422-0067/23/1/258 |
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