Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways
Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clin...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1612 |
| _version_ | 1797620205784924160 |
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| author | Ciro Mauro Valentina Capone Rosangela Cocchia Filippo Cademartiri Ferdinando Riccardi Michele Arcopinto Maie Alshahid Kashif Anwar Mariano Carafa Andreina Carbone Rossana Castaldo Salvatore Chianese Giulia Crisci Roberta D’Assante Mariarosaria De Luca Monica Franzese Domenico Galzerano Vincenzo Maffei Alberto Maria Marra Alfredo Mazza Brigida Ranieri Anna D’Agostino Salvatore Rega Luigia Romano Sarah Scagliarini Chiara Sepe Olga Vriz Raffaele Izzo Antonio Cittadini Eduardo Bossone Andrea Salzano |
| author_facet | Ciro Mauro Valentina Capone Rosangela Cocchia Filippo Cademartiri Ferdinando Riccardi Michele Arcopinto Maie Alshahid Kashif Anwar Mariano Carafa Andreina Carbone Rossana Castaldo Salvatore Chianese Giulia Crisci Roberta D’Assante Mariarosaria De Luca Monica Franzese Domenico Galzerano Vincenzo Maffei Alberto Maria Marra Alfredo Mazza Brigida Ranieri Anna D’Agostino Salvatore Rega Luigia Romano Sarah Scagliarini Chiara Sepe Olga Vriz Raffaele Izzo Antonio Cittadini Eduardo Bossone Andrea Salzano |
| author_sort | Ciro Mauro |
| collection | DOAJ |
| description | Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clinical index of suspicion is required by the multidisciplinary care team in order to trigger specific laboratory tests (namely natriuretic peptides and high-sensitivity cardiac troponin) and appropriate imaging techniques (transthoracic echocardiography along with cardiac magnetic resonance, cardiac computed tomography, and nuclear testing (if clinically indicated)), leading to timely diagnosis. In the near future, we do expect a more tailored approach to patient care within the respective community along with the widespread implementation of digital health tools. |
| first_indexed | 2024-03-11T08:37:46Z |
| format | Article |
| id | doaj.art-8bc3788173e94651a206e9cc6711ee5e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:37:46Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8bc3788173e94651a206e9cc6711ee5e2023-11-16T21:22:02ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124161210.3390/jcm12041612Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic PathwaysCiro Mauro0Valentina Capone1Rosangela Cocchia2Filippo Cademartiri3Ferdinando Riccardi4Michele Arcopinto5Maie Alshahid6Kashif Anwar7Mariano Carafa8Andreina Carbone9Rossana Castaldo10Salvatore Chianese11Giulia Crisci12Roberta D’Assante13Mariarosaria De Luca14Monica Franzese15Domenico Galzerano16Vincenzo Maffei17Alberto Maria Marra18Alfredo Mazza19Brigida Ranieri20Anna D’Agostino21Salvatore Rega22Luigia Romano23Sarah Scagliarini24Chiara Sepe25Olga Vriz26Raffaele Izzo27Antonio Cittadini28Eduardo Bossone29Andrea Salzano30Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyCardiology Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyCardiology Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, Via Moruzzi, 1, 56124 Pisa, ItalyOncology Unit, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyThe Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi ArabiaThe Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi ArabiaEmergency Medicine Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyUnit of Cardiology, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyIRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, ItalyCardiology Division, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyIRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, ItalyThe Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi ArabiaPost Operative Intensive Care Division, Antonio Cardarelli Hospital, 9, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyUnit of Cardiology, Camerino Hospital, 62032 Macerata, ItalyIRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, ItalyIRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, ItalyDepartment of Public Health, University Federico II of Naples, Via Sergio Pansini, 5, 80131 Naples, ItalyDepartment of General and Emergency Radiology, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyOncology Unit, Antonio Cardarelli Hospital, Via Cardarelli, 9, 80131 Naples, ItalyTechnical Nursing and Rehabilitation Service (SITR) Department, Cardarelli Hospital, 80131 Naples, ItalyThe Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi ArabiaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Sergio Pansini, 5, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80138 Naples, ItalyDepartment of Public Health, University Federico II of Naples, Via Sergio Pansini, 5, 80131 Naples, ItalyIRCCS SYNLAB SDN, Via Emanuele Gianturco, 113, 80143 Naples, ItalyEarly detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clinical index of suspicion is required by the multidisciplinary care team in order to trigger specific laboratory tests (namely natriuretic peptides and high-sensitivity cardiac troponin) and appropriate imaging techniques (transthoracic echocardiography along with cardiac magnetic resonance, cardiac computed tomography, and nuclear testing (if clinically indicated)), leading to timely diagnosis. In the near future, we do expect a more tailored approach to patient care within the respective community along with the widespread implementation of digital health tools.https://www.mdpi.com/2077-0383/12/4/1612cardio-oncologycancer therapy-related cardiovascular toxicitychemotherapy |
| spellingShingle | Ciro Mauro Valentina Capone Rosangela Cocchia Filippo Cademartiri Ferdinando Riccardi Michele Arcopinto Maie Alshahid Kashif Anwar Mariano Carafa Andreina Carbone Rossana Castaldo Salvatore Chianese Giulia Crisci Roberta D’Assante Mariarosaria De Luca Monica Franzese Domenico Galzerano Vincenzo Maffei Alberto Maria Marra Alfredo Mazza Brigida Ranieri Anna D’Agostino Salvatore Rega Luigia Romano Sarah Scagliarini Chiara Sepe Olga Vriz Raffaele Izzo Antonio Cittadini Eduardo Bossone Andrea Salzano Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways Journal of Clinical Medicine cardio-oncology cancer therapy-related cardiovascular toxicity chemotherapy |
| title | Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways |
| title_full | Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways |
| title_fullStr | Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways |
| title_full_unstemmed | Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways |
| title_short | Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways |
| title_sort | exploring the cardiotoxicity spectrum of anti cancer treatments definition classification and diagnostic pathways |
| topic | cardio-oncology cancer therapy-related cardiovascular toxicity chemotherapy |
| url | https://www.mdpi.com/2077-0383/12/4/1612 |
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