Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea
Background and Aim: Obstructive sleep apnea (OSA) is one of the most common sleep disorders that, despite the high prevalence, most people are unaware of it. The reason for this disorder is obstruction of the respiratory tract, which reduces blood oxygen as a result of frequent waking during the nig...
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| Format: | Article |
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Tehran University of Medical Sciences
2018-09-01
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| Series: | پیاورد سلامت |
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| Online Access: | http://payavard.tums.ac.ir/article-1-6571-en.html |
| _version_ | 1818881116852977664 |
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| author | Parichehr Hanachi Zahra Ghaseminya Khosro Sadeghniyat Abolfazl Golestani |
| author_facet | Parichehr Hanachi Zahra Ghaseminya Khosro Sadeghniyat Abolfazl Golestani |
| author_sort | Parichehr Hanachi |
| collection | DOAJ |
| description | Background and Aim: Obstructive sleep apnea (OSA) is one of the most common sleep disorders that, despite the high prevalence, most people are unaware of it. The reason for this disorder is obstruction of the respiratory tract, which reduces blood oxygen as a result of frequent waking during the night. In this study, the status of antioxidant defense was considered as one of the most important mechanisms involved in preventing the consequences of this complication.
Materials and Methods: The 35 subjects of OSA were selected and categorized according to the apnea-hypopnea index (AHI) in two groups: Mild OSA (n=17) and severe OSA (n=18). The fasting blood samples were taken in order to evaluate the antioxidant defense status of the glutathione peroxidase activity (GPx) and glutathione (GSH) content.
Results: The results showed the mean values for GPx in patients with mild and severe apnea were 36.6±2.2 and 35.3±3.7 (u/gHb), respectively. Also, the mean values for GSH content in patients with mild and severe apnea were 0.54±0.1 and 0.68±0.1 µM, respectively that showed a 23% increase (P˂0.05) in severe apnea patients.
Conclusion: There was no significant difference in the GPx activity of mild apnea, however, patients with severe apnea showed a significant increase in GSH levels compared to mild apnea (P<0.05), which may indicate a long-term response to oxidative stress alters gene expression and increases the level of these biomarkers in a long time. |
| first_indexed | 2024-12-19T14:56:45Z |
| format | Article |
| id | doaj.art-8bc3f1fe965246698eb9f6c425d9a392 |
| institution | Directory Open Access Journal |
| issn | 1735-8132 2008-2665 |
| language | fas |
| last_indexed | 2024-12-19T14:56:45Z |
| publishDate | 2018-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | پیاورد سلامت |
| spelling | doaj.art-8bc3f1fe965246698eb9f6c425d9a3922022-12-21T20:16:41ZfasTehran University of Medical Sciencesپیاورد سلامت1735-81322008-26652018-09-01123193200Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep ApneaParichehr Hanachi0Zahra Ghaseminya1Khosro Sadeghniyat2Abolfazl Golestani3 Associate Professor, Biotechnology Department, School of Biological Sciences, Alzahra University, Tehran, Iran Master of Science in Biochemistry, Biotechnology Department, School of Biological Sciences, Alzahra University, Tehran, Iran Professor, Occupational Medicine Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Professor, Biochemistry Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Background and Aim: Obstructive sleep apnea (OSA) is one of the most common sleep disorders that, despite the high prevalence, most people are unaware of it. The reason for this disorder is obstruction of the respiratory tract, which reduces blood oxygen as a result of frequent waking during the night. In this study, the status of antioxidant defense was considered as one of the most important mechanisms involved in preventing the consequences of this complication. Materials and Methods: The 35 subjects of OSA were selected and categorized according to the apnea-hypopnea index (AHI) in two groups: Mild OSA (n=17) and severe OSA (n=18). The fasting blood samples were taken in order to evaluate the antioxidant defense status of the glutathione peroxidase activity (GPx) and glutathione (GSH) content. Results: The results showed the mean values for GPx in patients with mild and severe apnea were 36.6±2.2 and 35.3±3.7 (u/gHb), respectively. Also, the mean values for GSH content in patients with mild and severe apnea were 0.54±0.1 and 0.68±0.1 µM, respectively that showed a 23% increase (P˂0.05) in severe apnea patients. Conclusion: There was no significant difference in the GPx activity of mild apnea, however, patients with severe apnea showed a significant increase in GSH levels compared to mild apnea (P<0.05), which may indicate a long-term response to oxidative stress alters gene expression and increases the level of these biomarkers in a long time.http://payavard.tums.ac.ir/article-1-6571-en.htmlapneaoxidative stressantioxidant defense |
| spellingShingle | Parichehr Hanachi Zahra Ghaseminya Khosro Sadeghniyat Abolfazl Golestani Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea پیاورد سلامت apnea oxidative stress antioxidant defense |
| title | Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea |
| title_full | Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea |
| title_fullStr | Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea |
| title_full_unstemmed | Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea |
| title_short | Comparison of Oxidative Stress Effects on Enzymatic and Non-Enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea |
| title_sort | comparison of oxidative stress effects on enzymatic and non enzymatic indices in patients with mild and severe obstructive sleep apnea |
| topic | apnea oxidative stress antioxidant defense |
| url | http://payavard.tums.ac.ir/article-1-6571-en.html |
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