Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/1/24 |
| _version_ | 1797414603872796672 |
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| author | Mariano Catanesi Giulia Caioni Vanessa Castelli Elisabetta Benedetti Michele d’Angelo Annamaria Cimini |
| author_facet | Mariano Catanesi Giulia Caioni Vanessa Castelli Elisabetta Benedetti Michele d’Angelo Annamaria Cimini |
| author_sort | Mariano Catanesi |
| collection | DOAJ |
| description | Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. |
| first_indexed | 2024-03-09T05:35:43Z |
| format | Article |
| id | doaj.art-8bc4c1ee159d4cc5b0c621106cf20570 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T05:35:43Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8bc4c1ee159d4cc5b0c621106cf205702023-12-03T12:28:49ZengMDPI AGMarine Drugs1660-33972021-01-011912410.3390/md19010024Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative DisordersMariano Catanesi0Giulia Caioni1Vanessa Castelli2Elisabetta Benedetti3Michele d’Angelo4Annamaria Cimini5Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, ItalyMarine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.https://www.mdpi.com/1660-3397/19/1/24marine drugsneurodegenerative diseasesParkinson’s diseaseAlzheimer’s diseasebrainantioxidants |
| spellingShingle | Mariano Catanesi Giulia Caioni Vanessa Castelli Elisabetta Benedetti Michele d’Angelo Annamaria Cimini Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders Marine Drugs marine drugs neurodegenerative diseases Parkinson’s disease Alzheimer’s disease brain antioxidants |
| title | Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
| title_full | Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
| title_fullStr | Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
| title_full_unstemmed | Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
| title_short | Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
| title_sort | benefits under the sea the role of marine compounds in neurodegenerative disorders |
| topic | marine drugs neurodegenerative diseases Parkinson’s disease Alzheimer’s disease brain antioxidants |
| url | https://www.mdpi.com/1660-3397/19/1/24 |
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