Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms
AIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms. <p>METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2015/5/201505024.pdf |
| Summary: | AIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms. <p>METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control group. The observation group were divided into chronic and acute primary angle-closure glaucoma groups, then multiplex PCR technology was used to detect the genetic polymorphisms of GSTM1 and GSTT1. <p>RESULTS:The distribution frequencies of GSTT1-null genotype were 54.3%, while it was 54.0% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.053, <i>P</i>>0.05); The frequency GSTT1-null genotype in chronic group of primary angle-closure glaucoma was 54.9%, while it was 48.6% in the acute group of primary angle-closure glaucoma, statistically no significance between control group and acute group(<i>χ</i><sup>2</sup>=0.064, <i>P</i>>0.05), and chronic group(<i>χ</i><sup>2</sup>=0.037, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 59.0%, while it was 55.7% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.013, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 62.3% and 58.1% in acute and chronic group of primary angle-closure glaucoma patients respectively. Acute group of primary angle-closure glaucoma has no significant compared with control group(<i>χ</i><sup>2</sup>=0.005, <i>P</i>>0.05), Chronic group of primary angle-closure glaucoma had no significant compared with control group(<i>χ</i><sup>2</sup>=0.047, <i>P</i>>0.05). <p>CONCLUSION:No statistic significance relationship is found between primary angle-closure glaucom patients and the null genotypes of GSTM1 and GSTT1 susceptibility. |
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| ISSN: | 1672-5123 1672-5123 |