Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms
AIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms. <p>METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-05-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2015/5/201505024.pdf |
| _version_ | 1819144552330559488 |
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| author | Li-Dan Luo |
| author_facet | Li-Dan Luo |
| author_sort | Li-Dan Luo |
| collection | DOAJ |
| description | AIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms. <p>METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control group. The observation group were divided into chronic and acute primary angle-closure glaucoma groups, then multiplex PCR technology was used to detect the genetic polymorphisms of GSTM1 and GSTT1. <p>RESULTS:The distribution frequencies of GSTT1-null genotype were 54.3%, while it was 54.0% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.053, <i>P</i>>0.05); The frequency GSTT1-null genotype in chronic group of primary angle-closure glaucoma was 54.9%, while it was 48.6% in the acute group of primary angle-closure glaucoma, statistically no significance between control group and acute group(<i>χ</i><sup>2</sup>=0.064, <i>P</i>>0.05), and chronic group(<i>χ</i><sup>2</sup>=0.037, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 59.0%, while it was 55.7% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.013, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 62.3% and 58.1% in acute and chronic group of primary angle-closure glaucoma patients respectively. Acute group of primary angle-closure glaucoma has no significant compared with control group(<i>χ</i><sup>2</sup>=0.005, <i>P</i>>0.05), Chronic group of primary angle-closure glaucoma had no significant compared with control group(<i>χ</i><sup>2</sup>=0.047, <i>P</i>>0.05). <p>CONCLUSION:No statistic significance relationship is found between primary angle-closure glaucom patients and the null genotypes of GSTM1 and GSTT1 susceptibility. |
| first_indexed | 2024-12-22T12:43:57Z |
| format | Article |
| id | doaj.art-8bc5a8cfb39446b18427ba2e19eb68d1 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-22T12:43:57Z |
| publishDate | 2015-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-8bc5a8cfb39446b18427ba2e19eb68d12022-12-21T18:25:21ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-05-0115583683810.3980/j.issn.1672-5123.2015.5.24Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphismsLi-Dan Luo0Department of Ophthalmology, Meizhou People's Hospital, Meizhou 514031, Guangdong Province, ChinaAIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms. <p>METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control group. The observation group were divided into chronic and acute primary angle-closure glaucoma groups, then multiplex PCR technology was used to detect the genetic polymorphisms of GSTM1 and GSTT1. <p>RESULTS:The distribution frequencies of GSTT1-null genotype were 54.3%, while it was 54.0% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.053, <i>P</i>>0.05); The frequency GSTT1-null genotype in chronic group of primary angle-closure glaucoma was 54.9%, while it was 48.6% in the acute group of primary angle-closure glaucoma, statistically no significance between control group and acute group(<i>χ</i><sup>2</sup>=0.064, <i>P</i>>0.05), and chronic group(<i>χ</i><sup>2</sup>=0.037, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 59.0%, while it was 55.7% in the control group, statistically no significance between control group and observation group(<i>χ</i><sup>2</sup>=0.013, <i>P</i>>0.05); The distribution frequencies of GSTM1-null genotype was 62.3% and 58.1% in acute and chronic group of primary angle-closure glaucoma patients respectively. Acute group of primary angle-closure glaucoma has no significant compared with control group(<i>χ</i><sup>2</sup>=0.005, <i>P</i>>0.05), Chronic group of primary angle-closure glaucoma had no significant compared with control group(<i>χ</i><sup>2</sup>=0.047, <i>P</i>>0.05). <p>CONCLUSION:No statistic significance relationship is found between primary angle-closure glaucom patients and the null genotypes of GSTM1 and GSTT1 susceptibility.http://ies.ijo.cn/cn_publish/2015/5/201505024.pdfprimary angle-closure glaucomagenetic polymorphismglutathione S-transgerase |
| spellingShingle | Li-Dan Luo Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms Guoji Yanke Zazhi primary angle-closure glaucoma genetic polymorphism glutathione S-transgerase |
| title | Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms |
| title_full | Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms |
| title_fullStr | Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms |
| title_full_unstemmed | Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms |
| title_short | Relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1 and M1 polymorphisms |
| title_sort | relationship of susceptibility of primary angle closure glaucoma with glutathione s transferase t1 and m1 polymorphisms |
| topic | primary angle-closure glaucoma genetic polymorphism glutathione S-transgerase |
| url | http://ies.ijo.cn/cn_publish/2015/5/201505024.pdf |
| work_keys_str_mv | AT lidanluo relationshipofsusceptibilityofprimaryangleclosureglaucomawithglutathionestransferaset1andm1polymorphisms |