| Summary: | INTRODUCTION: The aim of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on Nuclear Factor Kappa Beta (Nf-κβ) and inducible nitric oxide synthase (iNOS) activity against hepatic injury with chest trauma model in rats. METHODS: In the study, 40 adult Wistar albino male rats were divided into 4 groups respectively; control, chest trauma, chest trauma+CAPE and CAPE groups. CAPE administration was performed intraperitoneally at a dose of 10 μmol / kg / day for 7 days. At the end of the experiment, histopathologic changes were determined by hematoxylin-eosin (H&E) stain in liver tissue. In addition, hepatic Nf-κβ and iNOS activities were examined by indirect immunohistochemical method. RESULTS: Degeneration of hepatocyte cords and sinusoidal dilatation findings were found in the chest trauma group. Histopathological findings of chest trauma + CAPE group were found to be milder than chest trauma group. In addition, a statistically significant reduction in hepatic Nf-κβ and iNOS immunoreactivity was seen in the chest trauma + CAPE group compared to the chest trauma group (p<0.05). DISCUSSION AND CONCLUSION: CAPE has been shown to exert protective effects by suppressing Nf-κβ and iNOS activity in chest trauma induced hepatic damage in rats.
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