Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats
INTRODUCTION: The aim of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on Nuclear Factor Kappa Beta (Nf-κβ) and inducible nitric oxide synthase (iNOS) activity against hepatic injury with chest trauma model in rats. METHODS: In the study, 40 adult...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2019-04-01
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| Series: | Van Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-36097 |
| _version_ | 1797421129256665088 |
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| author | İhsan Karaboğa |
| author_facet | İhsan Karaboğa |
| author_sort | İhsan Karaboğa |
| collection | DOAJ |
| description | INTRODUCTION: The aim of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on Nuclear Factor Kappa Beta (Nf-κβ) and inducible nitric oxide synthase (iNOS) activity against hepatic injury with chest trauma model in rats. METHODS: In the study, 40 adult Wistar albino male rats were divided into 4 groups respectively; control, chest trauma, chest trauma+CAPE and CAPE groups. CAPE administration was performed intraperitoneally at a dose of 10 μmol / kg / day for 7 days. At the end of the experiment, histopathologic changes were determined by hematoxylin-eosin (H&E) stain in liver tissue. In addition, hepatic Nf-κβ and iNOS activities were examined by indirect immunohistochemical method. RESULTS: Degeneration of hepatocyte cords and sinusoidal dilatation findings were found in the chest trauma group. Histopathological findings of chest trauma + CAPE group were found to be milder than chest trauma group. In addition, a statistically significant reduction in hepatic Nf-κβ and iNOS immunoreactivity was seen in the chest trauma + CAPE group compared to the chest trauma group (p<0.05). DISCUSSION AND CONCLUSION: CAPE has been shown to exert protective effects by suppressing Nf-κβ and iNOS activity in chest trauma induced hepatic damage in rats. |
| first_indexed | 2024-03-09T07:11:29Z |
| format | Article |
| id | doaj.art-8bc7199b10054832905c0e30a12a252f |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T07:11:29Z |
| publishDate | 2019-04-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-8bc7199b10054832905c0e30a12a252f2023-12-03T09:01:21ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512019-04-0126222022510.5505/vtd.2019.36097VTD-36097Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Ratsİhsan Karaboğa0Namık Kemal University, School Of HealthINTRODUCTION: The aim of this study was to investigate the effect of caffeic acid phenethyl ester (CAPE) on Nuclear Factor Kappa Beta (Nf-κβ) and inducible nitric oxide synthase (iNOS) activity against hepatic injury with chest trauma model in rats. METHODS: In the study, 40 adult Wistar albino male rats were divided into 4 groups respectively; control, chest trauma, chest trauma+CAPE and CAPE groups. CAPE administration was performed intraperitoneally at a dose of 10 μmol / kg / day for 7 days. At the end of the experiment, histopathologic changes were determined by hematoxylin-eosin (H&E) stain in liver tissue. In addition, hepatic Nf-κβ and iNOS activities were examined by indirect immunohistochemical method. RESULTS: Degeneration of hepatocyte cords and sinusoidal dilatation findings were found in the chest trauma group. Histopathological findings of chest trauma + CAPE group were found to be milder than chest trauma group. In addition, a statistically significant reduction in hepatic Nf-κβ and iNOS immunoreactivity was seen in the chest trauma + CAPE group compared to the chest trauma group (p<0.05). DISCUSSION AND CONCLUSION: CAPE has been shown to exert protective effects by suppressing Nf-κβ and iNOS activity in chest trauma induced hepatic damage in rats.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-36097traumacaffeic acid phenethly esternitric oxide synthasenf-kappa b |
| spellingShingle | İhsan Karaboğa Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats Van Tıp Dergisi trauma caffeic acid phenethly ester nitric oxide synthase nf-kappa b |
| title | Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats |
| title_full | Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats |
| title_fullStr | Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats |
| title_full_unstemmed | Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats |
| title_short | Caffeic Acid Phenethyl Ester Reduces Hepatic Injury Following Chest Trauma by Supressing Nuclear Factor Kappa Beta and Inducible Nitric Oxide Synthase in Rats |
| title_sort | caffeic acid phenethyl ester reduces hepatic injury following chest trauma by supressing nuclear factor kappa beta and inducible nitric oxide synthase in rats |
| topic | trauma caffeic acid phenethly ester nitric oxide synthase nf-kappa b |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-36097 |
| work_keys_str_mv | AT ihsankaraboga caffeicacidphenethylesterreduceshepaticinjuryfollowingchesttraumabysupressingnuclearfactorkappabetaandinduciblenitricoxidesynthaseinrats |