HCV Core/NS3 Protein Immunization with “N-Terminal Heat Shock gp96 Protein (rNT (gp96))” Induced Strong and Sustained Th1-Type Cytokines in Immunized Mice

HCV Core/NS3 Protein Immunization with “N-Terminal Heat Shock gp96 Protein (rNT (gp96))” Induced Strong and Sustained Th1-Type Cytokines in Immunized Mice

Feeble cellular responses induced by T cell-based vaccines are a major challenge for the development of an effective vaccine against Hepatitis C virus (HCV) infection. To address this challenge, the potential of N-terminal fragment of gp96 heat shock protein (rNT (gp96) as an adjuvant was evaluated...

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Bibliographic Details
Main Authors: Zamaneh Hajikhezri, Farzin Roohvand, Monireh Maleki, Shohreh Shahmahmoodi, Ali Akbar Amirzargar, Abolfazl Keshavarz, Negar Seyed, Mohammad Farahmand, Katayoun Samimi-Rad
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
Hepatitis C virus
rNT (gp96)
vaccine
Core-Ns3
prime-boost
Online Access:https://www.mdpi.com/2076-393X/9/3/215

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