Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury

Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects of Apamin in a Murine Model of Lipopolysaccharide-Induced Acute Kidney Injury

Sepsis is the major cause of acute kidney injury (AKI) in severely ill patients, but only limited therapeutic options are available. During sepsis, lipopolysaccharide (LPS), an endotoxin derived from bacteria, activates signaling cascades involved in inflammatory responses and tissue injury. Apamin...

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Bibliographic Details
Main Authors: Jung-Yeon Kim, Jaechan Leem, Kwan-Kyu Park
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
acute kidney injury
sepsis
apamin
lipopolysaccharide
oxidative stress
apoptosis
Online Access:https://www.mdpi.com/1420-3049/25/23/5717

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