Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it>
<p>Abstract</p> <p>Background</p> <p><it>Cichorium glandulosum</it> Boiss. et Huet is used for treatment of liver disorders, and its effects are attributed to sesquiterpenes. This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | Chinese Medicine |
| Online Access: | http://www.cmjournal.org/content/7/1/21 |
| _version_ | 1818527849218310144 |
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| author | Yang Wei-Jun Luo Yu-Qin Aisa Haji Xin Xue-Lei Totahon Z Mao Yan Hu Meng-Ying Xu Lei Zhang Rui-Ping |
| author_facet | Yang Wei-Jun Luo Yu-Qin Aisa Haji Xin Xue-Lei Totahon Z Mao Yan Hu Meng-Ying Xu Lei Zhang Rui-Ping |
| author_sort | Yang Wei-Jun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Cichorium glandulosum</it> Boiss. et Huet is used for treatment of liver disorders, and its effects are attributed to sesquiterpenes. This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich fraction (SRF) from the aerial part of <it>C. glandulosum</it> on carbon tetrachloride (CCl<sub>4</sub>)-induced acute hepatotoxicity in mice, and on priming with Bacillus Calmette–Guerin (BCG) followed by lipopolysaccharide (LPS)-induced immunological liver injury in mice.</p> <p>Methods</p> <p>SRF was suspended in water and administered to mice at 0.05, 0.10 and 0.20 g/kg body weight for 7 consecutive days. An active control drug (bifendate pills) was suspended in distilled water and administered to mice at 0.40 g/kg body weight for 7 consecutive days. Hepatotoxicity was induced by intraperitoneal injection of 0.1% CCl<sub>4</sub> (0.2 mL/mouse) at 13 h before the last drug administration, or by tail intravenous injection of BCG (0.2 mL/mouse) before the first drug administration and LPS (0.2 mL/mouse; 8 μg) at 15 h before the last drug administration. Blood samples and the livers were collected for evaluation of the biochemical parameters of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL).</p> <p>Results</p> <p>SRF significantly reduced the impact of CCl<sub>4</sub> toxicity. The highest dose of SRF (0.20 g/kg) was the most effective, reflected by significant reductions in the levels of AST (<it>P</it> = 0.001), ALT (<it>P</it> = 0.000) and TBIL (<it>P</it> = 0.009). The serum enzymatic levels induced by BCG and subsequent LPS injection were significantly and dose-dependently restored by SRF, reflected by significant reductions in the levels of AST (<it>P</it> = 0.003), ALT (<it>P</it> = 0.003) and TBIL (<it>P</it> = 0.007) for the highest dose of SRF (0.20 g/kg).</p> <p>Conclusion</p> <p>SRF is hepatoprotective in animal models of chemical and immunological acute liver injury.</p> |
| first_indexed | 2024-12-11T06:41:42Z |
| format | Article |
| id | doaj.art-8bc74c41736746a4b5c83f2c106a9de4 |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-12-11T06:41:42Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
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| series | Chinese Medicine |
| spelling | doaj.art-8bc74c41736746a4b5c83f2c106a9de42022-12-22T01:17:12ZengBMCChinese Medicine1749-85462012-09-01712110.1186/1749-8546-7-21Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it>Yang Wei-JunLuo Yu-QinAisa HajiXin Xue-LeiTotahon ZMao YanHu Meng-YingXu LeiZhang Rui-Ping<p>Abstract</p> <p>Background</p> <p><it>Cichorium glandulosum</it> Boiss. et Huet is used for treatment of liver disorders, and its effects are attributed to sesquiterpenes. This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich fraction (SRF) from the aerial part of <it>C. glandulosum</it> on carbon tetrachloride (CCl<sub>4</sub>)-induced acute hepatotoxicity in mice, and on priming with Bacillus Calmette–Guerin (BCG) followed by lipopolysaccharide (LPS)-induced immunological liver injury in mice.</p> <p>Methods</p> <p>SRF was suspended in water and administered to mice at 0.05, 0.10 and 0.20 g/kg body weight for 7 consecutive days. An active control drug (bifendate pills) was suspended in distilled water and administered to mice at 0.40 g/kg body weight for 7 consecutive days. Hepatotoxicity was induced by intraperitoneal injection of 0.1% CCl<sub>4</sub> (0.2 mL/mouse) at 13 h before the last drug administration, or by tail intravenous injection of BCG (0.2 mL/mouse) before the first drug administration and LPS (0.2 mL/mouse; 8 μg) at 15 h before the last drug administration. Blood samples and the livers were collected for evaluation of the biochemical parameters of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL).</p> <p>Results</p> <p>SRF significantly reduced the impact of CCl<sub>4</sub> toxicity. The highest dose of SRF (0.20 g/kg) was the most effective, reflected by significant reductions in the levels of AST (<it>P</it> = 0.001), ALT (<it>P</it> = 0.000) and TBIL (<it>P</it> = 0.009). The serum enzymatic levels induced by BCG and subsequent LPS injection were significantly and dose-dependently restored by SRF, reflected by significant reductions in the levels of AST (<it>P</it> = 0.003), ALT (<it>P</it> = 0.003) and TBIL (<it>P</it> = 0.007) for the highest dose of SRF (0.20 g/kg).</p> <p>Conclusion</p> <p>SRF is hepatoprotective in animal models of chemical and immunological acute liver injury.</p>http://www.cmjournal.org/content/7/1/21 |
| spellingShingle | Yang Wei-Jun Luo Yu-Qin Aisa Haji Xin Xue-Lei Totahon Z Mao Yan Hu Meng-Ying Xu Lei Zhang Rui-Ping Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> Chinese Medicine |
| title | Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> |
| title_full | Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> |
| title_fullStr | Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> |
| title_full_unstemmed | Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> |
| title_short | Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of <it>Cichorium glandulosum</it> |
| title_sort | hepatoprotective activities of a sesquiterpene rich fraction from the aerial part of it cichorium glandulosum it |
| url | http://www.cmjournal.org/content/7/1/21 |
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