Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide
1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and the slurry crystallization methods. X-ray single crystal diffraction of DPA:TA confirmed the formation of salt by the transfer of an acidic proton from one of the carboxylic acidic groups of T...
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MDPI AG
2021-03-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/11/4/368 |
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| author | Majid Ismail Tamboli Yohei Utusmi Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi |
| author_facet | Majid Ismail Tamboli Yohei Utusmi Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi |
| author_sort | Majid Ismail Tamboli |
| collection | DOAJ |
| description | 1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and the slurry crystallization methods. X-ray single crystal diffraction of DPA:TA confirmed the formation of salt by the transfer of an acidic proton from one of the carboxylic acidic groups of TA to the tertiary amino group of the chain moiety (N3-nitrogen atom) of the DPA molecules. DPA:TA salt crystals crystalize in the triclinic system with space group <i>P</i>-1. The asymmetric unit, comprising one protonated DPA and one TA anion, are linked by a strong charge assisted N<sup>+</sup>–H∙∙∙O¯ hydrogen bond and a C–H∙∙∙O¯ hydrogen bond. Moreover, structural characterization of DPA:TA salt was carried out using Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, and powder X-ray diffraction techniques |
| first_indexed | 2024-03-10T12:44:39Z |
| format | Article |
| id | doaj.art-8bc80881941f43548b9e57dc0b83acb9 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T12:44:39Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-8bc80881941f43548b9e57dc0b83acb92023-11-21T13:34:54ZengMDPI AGCrystals2073-43522021-03-0111436810.3390/cryst11040368Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug DisopyramideMajid Ismail Tamboli0Yohei Utusmi1Takayuki Furuishi2Kaori Fukuzawa3Etsuo Yonemochi4Department of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JapanDepartment of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and the slurry crystallization methods. X-ray single crystal diffraction of DPA:TA confirmed the formation of salt by the transfer of an acidic proton from one of the carboxylic acidic groups of TA to the tertiary amino group of the chain moiety (N3-nitrogen atom) of the DPA molecules. DPA:TA salt crystals crystalize in the triclinic system with space group <i>P</i>-1. The asymmetric unit, comprising one protonated DPA and one TA anion, are linked by a strong charge assisted N<sup>+</sup>–H∙∙∙O¯ hydrogen bond and a C–H∙∙∙O¯ hydrogen bond. Moreover, structural characterization of DPA:TA salt was carried out using Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, and powder X-ray diffraction techniqueshttps://www.mdpi.com/2073-4352/11/4/368DisopyramideTerephthalic acidsaltcrystal structuremolecular packingslurry crystallization |
| spellingShingle | Majid Ismail Tamboli Yohei Utusmi Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide Crystals Disopyramide Terephthalic acid salt crystal structure molecular packing slurry crystallization |
| title | Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide |
| title_full | Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide |
| title_fullStr | Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide |
| title_full_unstemmed | Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide |
| title_short | Crystal Structure of Novel Terephthalate Salt of Antiarrhythmic Drug Disopyramide |
| title_sort | crystal structure of novel terephthalate salt of antiarrhythmic drug disopyramide |
| topic | Disopyramide Terephthalic acid salt crystal structure molecular packing slurry crystallization |
| url | https://www.mdpi.com/2073-4352/11/4/368 |
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