Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis
Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin...
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2458 |
| _version_ | 1797264520995930112 |
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| author | Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu |
| author_facet | Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu |
| author_sort | Lixing Cao |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin compound isolated from licorice that demonstrates various pharmacological activities. However, its potential for a protective effect against kidney injury remains unknown. We hypothesized that GC might be able to protect against AKI via suppression of ferroptosis. This hypothesis was tested in a cell-culture model of RSL3-induced nephrocyte ferroptosis and a mouse model of folic acid-induced AKI. The results showed that GC exerted a significant protective effect against nephrocyte ferroptosis in vitro and was effective against folic acid-induced AKI in vivo, where it was mechanistically associated with suppressing HO-1-mediated heme degradation. Collectively, the findings of the present study support the hypothesis that GC holds considerable potential to be developed as a novel agent for treating ferroptosis-related AKI. |
| first_indexed | 2024-04-25T00:30:13Z |
| format | Article |
| id | doaj.art-8bc8261257174fbfa012427ff452fedf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:30:13Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8bc8261257174fbfa012427ff452fedf2024-03-12T16:45:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255245810.3390/ijms25052458Glycyrol Alleviates Acute Kidney Injury by Inhibiting FerroptsisLixing Cao0Kai Han1Lihong Fan2Chong Zhao3Shutao Yin4Hongbo Hu5College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaAcute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin compound isolated from licorice that demonstrates various pharmacological activities. However, its potential for a protective effect against kidney injury remains unknown. We hypothesized that GC might be able to protect against AKI via suppression of ferroptosis. This hypothesis was tested in a cell-culture model of RSL3-induced nephrocyte ferroptosis and a mouse model of folic acid-induced AKI. The results showed that GC exerted a significant protective effect against nephrocyte ferroptosis in vitro and was effective against folic acid-induced AKI in vivo, where it was mechanistically associated with suppressing HO-1-mediated heme degradation. Collectively, the findings of the present study support the hypothesis that GC holds considerable potential to be developed as a novel agent for treating ferroptosis-related AKI.https://www.mdpi.com/1422-0067/25/5/2458glycyrolferroptosisacute kidney injuryHO-1 |
| spellingShingle | Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis International Journal of Molecular Sciences glycyrol ferroptosis acute kidney injury HO-1 |
| title | Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis |
| title_full | Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis |
| title_fullStr | Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis |
| title_full_unstemmed | Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis |
| title_short | Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis |
| title_sort | glycyrol alleviates acute kidney injury by inhibiting ferroptsis |
| topic | glycyrol ferroptosis acute kidney injury HO-1 |
| url | https://www.mdpi.com/1422-0067/25/5/2458 |
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