Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity
PM2.5 is a complex pollutant that is a pervasive threat to human health. The health risks and toxicity mechanisms of PM2.5 components must be identified to alleviate the corresponding risks. In this study, a reductionism approach based on model PM2.5 particles was used to investigate the contributio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323000660 |
| _version_ | 1797936466206130176 |
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| author | Xiujiao Pan Qianhui Yu Shenshu Chen Yaqing Li Taifeng Jiao Wenyue Li Chuchu Zhang Aliye Kureshi Lianghong Cheng Qiyong Xu |
| author_facet | Xiujiao Pan Qianhui Yu Shenshu Chen Yaqing Li Taifeng Jiao Wenyue Li Chuchu Zhang Aliye Kureshi Lianghong Cheng Qiyong Xu |
| author_sort | Xiujiao Pan |
| collection | DOAJ |
| description | PM2.5 is a complex pollutant that is a pervasive threat to human health. The health risks and toxicity mechanisms of PM2.5 components must be identified to alleviate the corresponding risks. In this study, a reductionism approach based on model PM2.5 particles was used to investigate the contributions of the most harmful components in PM2.5 to its toxicity. Human liver and kidney cells were used as models. The results showed that Cr(VI) was the most critical toxic component among other components (Pb, As, and benzo[a]pyrene) in human liver and kidney cells. PM2.5-Cr(VI) induced oxidative stress, which led to cytotoxicity by inducing cell cycle arrest in the S-phase in HepG2 and HEK293 cells. The presented findings can provide valuable insights into the toxicity levels of PM2.5 components, which can help clarify the potential health risks from PM2.5 exposure. |
| first_indexed | 2024-04-10T18:30:00Z |
| format | Article |
| id | doaj.art-8bcad569d18743f494c510e7d094f4ec |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T18:30:00Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-8bcad569d18743f494c510e7d094f4ec2023-02-02T04:47:07ZengElsevierEcotoxicology and Environmental Safety0147-65132023-02-01251114562Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicityXiujiao Pan0Qianhui Yu1Shenshu Chen2Yaqing Li3Taifeng Jiao4Wenyue Li5Chuchu Zhang6Aliye Kureshi7Lianghong Cheng8Qiyong Xu9School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Guangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaSchool of Environmental Science and Engineering, Shandong University, Jinan 250100, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, ChinaGuangdong Nantian Institute of Forensic Science, Shenzhen 518003, China; Corresponding authors.School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Corresponding authors.PM2.5 is a complex pollutant that is a pervasive threat to human health. The health risks and toxicity mechanisms of PM2.5 components must be identified to alleviate the corresponding risks. In this study, a reductionism approach based on model PM2.5 particles was used to investigate the contributions of the most harmful components in PM2.5 to its toxicity. Human liver and kidney cells were used as models. The results showed that Cr(VI) was the most critical toxic component among other components (Pb, As, and benzo[a]pyrene) in human liver and kidney cells. PM2.5-Cr(VI) induced oxidative stress, which led to cytotoxicity by inducing cell cycle arrest in the S-phase in HepG2 and HEK293 cells. The presented findings can provide valuable insights into the toxicity levels of PM2.5 components, which can help clarify the potential health risks from PM2.5 exposure.http://www.sciencedirect.com/science/article/pii/S0147651323000660Model PM2.5 particlesHuman liver and kidney cellToxic componentReductionismCell cycle arrest |
| spellingShingle | Xiujiao Pan Qianhui Yu Shenshu Chen Yaqing Li Taifeng Jiao Wenyue Li Chuchu Zhang Aliye Kureshi Lianghong Cheng Qiyong Xu Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity Ecotoxicology and Environmental Safety Model PM2.5 particles Human liver and kidney cell Toxic component Reductionism Cell cycle arrest |
| title | Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity |
| title_full | Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity |
| title_fullStr | Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity |
| title_full_unstemmed | Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity |
| title_short | Dissecting contributions of representative heavy metal components in PM2.5 to its cytotoxicity |
| title_sort | dissecting contributions of representative heavy metal components in pm2 5 to its cytotoxicity |
| topic | Model PM2.5 particles Human liver and kidney cell Toxic component Reductionism Cell cycle arrest |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323000660 |
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