Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review
BackgroundThe neural activity of irritable bowel syndrome (IBS) patients in the resting state without any intervention has not been systematically studied. The purpose of this study was to compare the resting-state brain functions of IBS patients with healthy controls (HCs).MethodsThe published neur...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.851586/full |
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| author | Zheng Yu Li-Ying Liu Yuan-Yuan Lai Zi-Lei Tian Lu Yang Qi Zhang Fan-Rong Liang Si-Yi Yu Qian-Hua Zheng |
| author_facet | Zheng Yu Li-Ying Liu Yuan-Yuan Lai Zi-Lei Tian Lu Yang Qi Zhang Fan-Rong Liang Si-Yi Yu Qian-Hua Zheng |
| author_sort | Zheng Yu |
| collection | DOAJ |
| description | BackgroundThe neural activity of irritable bowel syndrome (IBS) patients in the resting state without any intervention has not been systematically studied. The purpose of this study was to compare the resting-state brain functions of IBS patients with healthy controls (HCs).MethodsThe published neuroimage studies were obtained from electronic databases including PubMed, EMBASE, PsycINFO, Web of Science Core, CNKI Database, Wanfang Database, VIP Database, and CBMdisc. Search dates were from inception to March 14th, 2022. The studies were identified by the preidentified inclusion and exclusion criteria. Two independent reviewers compiled the studies and evaluated them for quality and bias.ResultsAltogether 22 fMRI studies were included in this review. The risk of bias of the included studies was generally low. The findings indicated that in IBS patients, increased or decreased brain areas were mostly associated with visceral sensations, emotional processing, and pain processing. According to brain network research, IBS may exhibit anomalies in the DMN, CEN, and emotional arousal networks. The fluctuations in emotion (anxiety, sadness) and symptoms in IBS patients were associated with alterations in the relevant brain regions.ConclusionThis study draws a preliminary conclusion that there are insufficient data to accurately distinguish the different neurological features of IBS in the resting state. Additional high-quality research undertaken by diverse geographic regions and teams is required to reach reliable results regarding resting-state changed brain regions in IBS. |
| first_indexed | 2024-04-13T07:40:19Z |
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| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T07:40:19Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-8bcae840078743f8991d74b6b749aa8a2022-12-22T02:55:55ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-04-011610.3389/fnhum.2022.851586851586Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic ReviewZheng Yu0Li-Ying Liu1Yuan-Yuan Lai2Zi-Lei Tian3Lu Yang4Qi Zhang5Fan-Rong Liang6Si-Yi Yu7Qian-Hua Zheng8College of Medical Information and Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChongqing Hospital of Traditional Chinese Medicine, Chongqing, ChinaCollege of Medical Information and Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBackgroundThe neural activity of irritable bowel syndrome (IBS) patients in the resting state without any intervention has not been systematically studied. The purpose of this study was to compare the resting-state brain functions of IBS patients with healthy controls (HCs).MethodsThe published neuroimage studies were obtained from electronic databases including PubMed, EMBASE, PsycINFO, Web of Science Core, CNKI Database, Wanfang Database, VIP Database, and CBMdisc. Search dates were from inception to March 14th, 2022. The studies were identified by the preidentified inclusion and exclusion criteria. Two independent reviewers compiled the studies and evaluated them for quality and bias.ResultsAltogether 22 fMRI studies were included in this review. The risk of bias of the included studies was generally low. The findings indicated that in IBS patients, increased or decreased brain areas were mostly associated with visceral sensations, emotional processing, and pain processing. According to brain network research, IBS may exhibit anomalies in the DMN, CEN, and emotional arousal networks. The fluctuations in emotion (anxiety, sadness) and symptoms in IBS patients were associated with alterations in the relevant brain regions.ConclusionThis study draws a preliminary conclusion that there are insufficient data to accurately distinguish the different neurological features of IBS in the resting state. Additional high-quality research undertaken by diverse geographic regions and teams is required to reach reliable results regarding resting-state changed brain regions in IBS.https://www.frontiersin.org/articles/10.3389/fnhum.2022.851586/fullirritable bowel syndromeneuroimagingbrain activityfMRIsystematic review |
| spellingShingle | Zheng Yu Li-Ying Liu Yuan-Yuan Lai Zi-Lei Tian Lu Yang Qi Zhang Fan-Rong Liang Si-Yi Yu Qian-Hua Zheng Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review Frontiers in Human Neuroscience irritable bowel syndrome neuroimaging brain activity fMRI systematic review |
| title | Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review |
| title_full | Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review |
| title_fullStr | Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review |
| title_full_unstemmed | Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review |
| title_short | Altered Resting Brain Functions in Patients With Irritable Bowel Syndrome: A Systematic Review |
| title_sort | altered resting brain functions in patients with irritable bowel syndrome a systematic review |
| topic | irritable bowel syndrome neuroimaging brain activity fMRI systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.851586/full |
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