Ocular allergy and keratoconus
Keratoconus is the most common corneal ectatic disorder, the cause of which is largely unknown. Many factors have been implicated, and the ocular allergy is being one of them. The commonly proposed pathogenesis includes the release of inflammatory mediators due to eye rubbing which may alter the cor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=407;epage=409;aulast=Sharma |
| _version_ | 1818614541643153408 |
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| author | Namrata Sharma Kavita Rao Prafulla K Maharana Rasik B Vajpayee |
| author_facet | Namrata Sharma Kavita Rao Prafulla K Maharana Rasik B Vajpayee |
| author_sort | Namrata Sharma |
| collection | DOAJ |
| description | Keratoconus is the most common corneal ectatic disorder, the cause of which is largely unknown. Many factors have been implicated, and the ocular allergy is being one of them. The commonly proposed pathogenesis includes the release of inflammatory mediators due to eye rubbing which may alter the corneal collagen and lead to corneal ectasias. The onset of keratoconus is often early in cases associated with allergy and routine corneal topography may detect subtle forms of keratoconus. These cases may require early keratoplasty and are at an increased risk of having acute corneal hydrops. Surgical outcomes are similar to primary keratoconus cases. However, post-operative epithelial breakdown may be a problem in these cases. Control of allergy and eye rubbing is the best measure to prevent corneal ectasias in cases of ocular allergy. |
| first_indexed | 2024-12-16T16:19:39Z |
| format | Article |
| id | doaj.art-8bcc0b47f6f04d5faa6105ad0fba6e6e |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-16T16:19:39Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-8bcc0b47f6f04d5faa6105ad0fba6e6e2022-12-21T22:24:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892013-01-0161840740910.4103/0301-4738.116063Ocular allergy and keratoconusNamrata SharmaKavita RaoPrafulla K MaharanaRasik B VajpayeeKeratoconus is the most common corneal ectatic disorder, the cause of which is largely unknown. Many factors have been implicated, and the ocular allergy is being one of them. The commonly proposed pathogenesis includes the release of inflammatory mediators due to eye rubbing which may alter the corneal collagen and lead to corneal ectasias. The onset of keratoconus is often early in cases associated with allergy and routine corneal topography may detect subtle forms of keratoconus. These cases may require early keratoplasty and are at an increased risk of having acute corneal hydrops. Surgical outcomes are similar to primary keratoconus cases. However, post-operative epithelial breakdown may be a problem in these cases. Control of allergy and eye rubbing is the best measure to prevent corneal ectasias in cases of ocular allergy.http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=407;epage=409;aulast=SharmaEpidemiologykeratoconusprevalenceDisease pathogenesisgenetic heterogeneitygenetics and genomicsgenome-wide association studygenomic locikeratoconuslinkage mappingmolecular mechanismswhole exome-genome sequencingDeregulationectasiagene expressionkeratoconusmass spectroscopyproteomicssignaling pathwaysCorneacrosslinkingkeratoconusmodulusCorneal topographyimagingkeratoconusoptical coherence tomographyplacido disc based topographyEctatic diseasekeratoconusscheimpflug imagingKeratoconusocular allergyvernal keratoconjunctivitis |
| spellingShingle | Namrata Sharma Kavita Rao Prafulla K Maharana Rasik B Vajpayee Ocular allergy and keratoconus Indian Journal of Ophthalmology Epidemiology keratoconus prevalence Disease pathogenesis genetic heterogeneity genetics and genomics genome-wide association study genomic loci keratoconus linkage mapping molecular mechanisms whole exome-genome sequencing Deregulation ectasia gene expression keratoconus mass spectroscopy proteomics signaling pathways Cornea crosslinking keratoconus modulus Corneal topography imaging keratoconus optical coherence tomography placido disc based topography Ectatic disease keratoconus scheimpflug imaging Keratoconus ocular allergy vernal keratoconjunctivitis |
| title | Ocular allergy and keratoconus |
| title_full | Ocular allergy and keratoconus |
| title_fullStr | Ocular allergy and keratoconus |
| title_full_unstemmed | Ocular allergy and keratoconus |
| title_short | Ocular allergy and keratoconus |
| title_sort | ocular allergy and keratoconus |
| topic | Epidemiology keratoconus prevalence Disease pathogenesis genetic heterogeneity genetics and genomics genome-wide association study genomic loci keratoconus linkage mapping molecular mechanisms whole exome-genome sequencing Deregulation ectasia gene expression keratoconus mass spectroscopy proteomics signaling pathways Cornea crosslinking keratoconus modulus Corneal topography imaging keratoconus optical coherence tomography placido disc based topography Ectatic disease keratoconus scheimpflug imaging Keratoconus ocular allergy vernal keratoconjunctivitis |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=407;epage=409;aulast=Sharma |
| work_keys_str_mv | AT namratasharma ocularallergyandkeratoconus AT kavitarao ocularallergyandkeratoconus AT prafullakmaharana ocularallergyandkeratoconus AT rasikbvajpayee ocularallergyandkeratoconus |