Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment
Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In...
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/2/417 |
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| author | Marlou-Floor Kenkhuis Floortje Mols Eline H. van Roekel José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Matty P. Weijenberg Martijn J. L. Bours |
| author_facet | Marlou-Floor Kenkhuis Floortje Mols Eline H. van Roekel José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Matty P. Weijenberg Martijn J. L. Bours |
| author_sort | Marlou-Floor Kenkhuis |
| collection | DOAJ |
| description | Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (<i>n</i> = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study. |
| first_indexed | 2024-03-10T01:46:19Z |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:46:19Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8bcc27d2c7ef44b28b058697e572c8482023-11-23T13:14:38ZengMDPI AGCancers2072-66942022-01-0114241710.3390/cancers14020417Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-TreatmentMarlou-Floor Kenkhuis0Floortje Mols1Eline H. van Roekel2José J. L. Breedveld-Peters3Stéphanie O. Breukink4Maryska L. G. Janssen-Heijnen5Eric T. P. Keulen6Fränzel J. B. van Duijnhoven7Matty P. Weijenberg8Martijn J. L. Bours9Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Medical and Clinical Psychology, Tilburg University, 5037 AB Tilburg, The NetherlandsDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Surgery, GROW School for Oncology and Developmental Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6229 HX Maastricht, The NetherlandsDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Internal Medicine and Gastroenterology, Zuyderland Medical Centre Sittard-Geleen, 6162 BG Geleen, The NetherlandsDivision of Human Nutrition and Health, Wageningen University & Research, 6708 PB Wageningen, The NetherlandsDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The NetherlandsPost-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (<i>n</i> = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.https://www.mdpi.com/2072-6694/14/2/417colorectal cancer survivorshiplifestyle recommendationshealth-related quality of lifefatiguechemotherapy-induced peripheral neuropathy |
| spellingShingle | Marlou-Floor Kenkhuis Floortje Mols Eline H. van Roekel José J. L. Breedveld-Peters Stéphanie O. Breukink Maryska L. G. Janssen-Heijnen Eric T. P. Keulen Fränzel J. B. van Duijnhoven Matty P. Weijenberg Martijn J. L. Bours Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment Cancers colorectal cancer survivorship lifestyle recommendations health-related quality of life fatigue chemotherapy-induced peripheral neuropathy |
| title | Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment |
| title_full | Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment |
| title_fullStr | Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment |
| title_full_unstemmed | Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment |
| title_short | Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment |
| title_sort | longitudinal associations of adherence to the world cancer research fund american institute for cancer research wcrf aicr lifestyle recommendations with quality of life and symptoms in colorectal cancer survivors up to 24 months post treatment |
| topic | colorectal cancer survivorship lifestyle recommendations health-related quality of life fatigue chemotherapy-induced peripheral neuropathy |
| url | https://www.mdpi.com/2072-6694/14/2/417 |
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