Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

There are no currently approved treatments for filovirus infections. In this study we report the discovery process which led to the development of antisense Phosphorodiamidate Morpholino Oligomers (PMOs) AVI-6002 (composed of AVI-7357 and AVI-7539) and AVI-6003 (composed of AVI-7287 and AVI-7288) ta...

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Bibliographic Details
Main Authors: Sina Bavari, Rekha G. Panchal, Dan V. Mourich, Lisa S. Welch, Nicole L. Garza, Jay B. Wells, Travis K. Warren, Patrick L. Iversen
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Viruses
Subjects:
Ebola
Marburg
Phosphorodiamidate Morpholino Oligomer
PMOplus
therapeutic
antiviral
Online Access:http://www.mdpi.com/1999-4915/4/11/2806

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