Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome
BackgroundThyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2015-02-01
|
| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-66.pdf |
| _version_ | 1818966422097756160 |
|---|---|
| author | Prabin Gyawali Jyoti Shrestha Takanche Raj Kumar Shrestha Prem Bhattarai Kishor Khanal Prabodh Risal Rajendra Koju |
| author_facet | Prabin Gyawali Jyoti Shrestha Takanche Raj Kumar Shrestha Prem Bhattarai Kishor Khanal Prabodh Risal Rajendra Koju |
| author_sort | Prabin Gyawali |
| collection | DOAJ |
| description | BackgroundThyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that coexistence of these two disease entities and unrecognized TD in patients with MetS might substantially increase ASCVD risk. Moreover, little is known about the relationship between TD and the components of MetS. Thus, the purpose of this study was to evaluate the pattern of TD in patients with MetS and its relationship with components of the MetS.MethodsA total of 358 previously diagnosed patients with MetS were recruited in the study. The thyroid function test parameters were measured to classify TD at Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal. Statistical analyses were performed using SPSS version 16.0 to evaluate pattern and relationship.ResultsThe overall prevalence of TD in patients with MetS was 31.84% with high prevalence of subclinical hypothyroidism (29.32%). We found no evidence of a relationship between TD and components of MetS, although there was significant difference in waist circumference between four groups of TD.ConclusionPatients with MetS had subclinical hypothyroidism greatly. Although there was no evidence of any relationship between thyroid status and all components of MetS, TD should be taken into account when evaluating and treating patients with MetS to reduce the impending risk. |
| first_indexed | 2024-12-20T13:32:39Z |
| format | Article |
| id | doaj.art-8bcdd7c1a5794c2a8e06405a8e2a860a |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-20T13:32:39Z |
| publishDate | 2015-02-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-8bcdd7c1a5794c2a8e06405a8e2a860a2022-12-21T19:39:03ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872015-02-01391667310.4093/dmj.2015.39.1.6614737Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic SyndromePrabin GyawaliJyoti Shrestha TakancheRaj Kumar ShresthaPrem BhattaraiKishor KhanalPrabodh RisalRajendra KojuBackgroundThyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that coexistence of these two disease entities and unrecognized TD in patients with MetS might substantially increase ASCVD risk. Moreover, little is known about the relationship between TD and the components of MetS. Thus, the purpose of this study was to evaluate the pattern of TD in patients with MetS and its relationship with components of the MetS.MethodsA total of 358 previously diagnosed patients with MetS were recruited in the study. The thyroid function test parameters were measured to classify TD at Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal. Statistical analyses were performed using SPSS version 16.0 to evaluate pattern and relationship.ResultsThe overall prevalence of TD in patients with MetS was 31.84% with high prevalence of subclinical hypothyroidism (29.32%). We found no evidence of a relationship between TD and components of MetS, although there was significant difference in waist circumference between four groups of TD.ConclusionPatients with MetS had subclinical hypothyroidism greatly. Although there was no evidence of any relationship between thyroid status and all components of MetS, TD should be taken into account when evaluating and treating patients with MetS to reduce the impending risk.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-66.pdfAtherosclerotic cardiovascular disease riskMetabolic syndromeSubclinical hypothyroidismThyroid dysfunction |
| spellingShingle | Prabin Gyawali Jyoti Shrestha Takanche Raj Kumar Shrestha Prem Bhattarai Kishor Khanal Prabodh Risal Rajendra Koju Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome Diabetes & Metabolism Journal Atherosclerotic cardiovascular disease risk Metabolic syndrome Subclinical hypothyroidism Thyroid dysfunction |
| title | Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome |
| title_full | Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome |
| title_fullStr | Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome |
| title_full_unstemmed | Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome |
| title_short | Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome |
| title_sort | pattern of thyroid dysfunction in patients with metabolic syndrome and its relationship with components of metabolic syndrome |
| topic | Atherosclerotic cardiovascular disease risk Metabolic syndrome Subclinical hypothyroidism Thyroid dysfunction |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-66.pdf |
| work_keys_str_mv | AT prabingyawali patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT jyotishresthatakanche patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT rajkumarshrestha patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT prembhattarai patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT kishorkhanal patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT prabodhrisal patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome AT rajendrakoju patternofthyroiddysfunctioninpatientswithmetabolicsyndromeanditsrelationshipwithcomponentsofmetabolicsyndrome |