Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials
Oral mucositis is a common and most debilitating complication associated with cancer therapy. Despite the significant clinical and economic impact of this condition, there is little to offer to patients with oral mucositis, and the medications used in its management are generally only palliative. Gi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/1/74 |
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| author | Giuseppe Colella Ciro Emiliano Boschetti Rita Vitagliano Chiara Colella Lebei Jiao Natalie King-Smith Chong Li Yii Nuoh Lau Zacchaeus Lai Ali Ibrahim Mohammed Nicola Cirillo |
| author_facet | Giuseppe Colella Ciro Emiliano Boschetti Rita Vitagliano Chiara Colella Lebei Jiao Natalie King-Smith Chong Li Yii Nuoh Lau Zacchaeus Lai Ali Ibrahim Mohammed Nicola Cirillo |
| author_sort | Giuseppe Colella |
| collection | DOAJ |
| description | Oral mucositis is a common and most debilitating complication associated with cancer therapy. Despite the significant clinical and economic impact of this condition, there is little to offer to patients with oral mucositis, and the medications used in its management are generally only palliative. Given that mucositis is ultimately a predictable and, therefore, potentially preventable condition, in this study we appraised the scientific literature to evaluate effective methods of prevention that have been tested in randomised controlled trials (RCTs). Published high-level evidence shows that multiple preventative methods are potentially effective in the prevention of oral mucositis induced by radiotherapy, chemotherapy, or both. Anti-inflammatory medications (including benzydamine), growth factors and cytokines (including palifermin), cryotherapy, laser-and-light therapy, herbal medicines and supplements, and mucoprotective agents (including oral pilocarpine) showed some degree of efficacy in preventing/reducing the severity of mucositis with most anticancer treatments. Allopurinol was potentially effective in the prevention of radiotherapy-induced oral mucositis; antimicrobial mouthwash and erythropoietin mouthwash were associated with a lower risk of development of severe oral mucositis induced by chemotherapy. The results of our review may assist in highlighting the efficacy and testing the effectiveness of low-cost, safe preventative measures for oral mucositis in cancer patients. |
| first_indexed | 2024-03-09T13:04:53Z |
| format | Article |
| id | doaj.art-8bce6c82c44545f880bf7b57a6a2855e |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:04:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-8bce6c82c44545f880bf7b57a6a2855e2023-11-30T21:49:54ZengMDPI AGCurrent Oncology1198-00521718-77292023-01-0130196798010.3390/curroncol30010074Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled TrialsGiuseppe Colella0Ciro Emiliano Boschetti1Rita Vitagliano2Chiara Colella3Lebei Jiao4Natalie King-Smith5Chong Li6Yii Nuoh Lau7Zacchaeus Lai8Ali Ibrahim Mohammed9Nicola Cirillo10Multidisciplinary Department of Medical-Surgical and Dental Specialties, Oral and Maxillofacial Surgery Unit, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMultidisciplinary Department of Medical-Surgical and Dental Specialties, Oral and Maxillofacial Surgery Unit, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMultidisciplinary Department of Medical-Surgical and Dental Specialties, Oral and Maxillofacial Surgery Unit, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMultidisciplinary Department of Medical-Surgical and Dental Specialties, Oral and Maxillofacial Surgery Unit, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, Carlton, Melbourne, VIC 3053, AustraliaOral mucositis is a common and most debilitating complication associated with cancer therapy. Despite the significant clinical and economic impact of this condition, there is little to offer to patients with oral mucositis, and the medications used in its management are generally only palliative. Given that mucositis is ultimately a predictable and, therefore, potentially preventable condition, in this study we appraised the scientific literature to evaluate effective methods of prevention that have been tested in randomised controlled trials (RCTs). Published high-level evidence shows that multiple preventative methods are potentially effective in the prevention of oral mucositis induced by radiotherapy, chemotherapy, or both. Anti-inflammatory medications (including benzydamine), growth factors and cytokines (including palifermin), cryotherapy, laser-and-light therapy, herbal medicines and supplements, and mucoprotective agents (including oral pilocarpine) showed some degree of efficacy in preventing/reducing the severity of mucositis with most anticancer treatments. Allopurinol was potentially effective in the prevention of radiotherapy-induced oral mucositis; antimicrobial mouthwash and erythropoietin mouthwash were associated with a lower risk of development of severe oral mucositis induced by chemotherapy. The results of our review may assist in highlighting the efficacy and testing the effectiveness of low-cost, safe preventative measures for oral mucositis in cancer patients.https://www.mdpi.com/1718-7729/30/1/74oral mucositisradiotherapychemotherapypreventative agents |
| spellingShingle | Giuseppe Colella Ciro Emiliano Boschetti Rita Vitagliano Chiara Colella Lebei Jiao Natalie King-Smith Chong Li Yii Nuoh Lau Zacchaeus Lai Ali Ibrahim Mohammed Nicola Cirillo Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials Current Oncology oral mucositis radiotherapy chemotherapy preventative agents |
| title | Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials |
| title_full | Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials |
| title_fullStr | Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials |
| title_full_unstemmed | Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials |
| title_short | Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials |
| title_sort | interventions for the prevention of oral mucositis in patients receiving cancer treatment evidence from randomised controlled trials |
| topic | oral mucositis radiotherapy chemotherapy preventative agents |
| url | https://www.mdpi.com/1718-7729/30/1/74 |
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