Type I Interferon Impairs Specific Antibody Responses Early During Establishment of LCMV Infection

Type I Interferon Impairs Specific Antibody Responses Early During Establishment of LCMV Infection

Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interactio...

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Bibliographic Details
Main Authors: Matthieu Daugan, Armstrong Murira, Barbara C Mindt, Amélie Germain, Esther Tarrab, Pascal Lapierre, Jorg Hermann Fritz, Alain Lamarre
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Antibody Formation
Interferon Type I
lcmv
neutralizing antibodies
immunopathology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00564/full

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