Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder
Abstract Objective This study aimed to investigate the differences in the relationship between hair cortisol concentration (HCC) and psychosocial stress, social support, clinical features, clinical course, and outcome in schizophrenia and bipolar disorder. Methods A total of 109 schizophrenia patien...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2412 |
| _version_ | 1797754663951400960 |
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| author | Fuzhong Yang Xiangfei Hong Jing Tao Yupeng Chen Yanbo Zhang Hua Xiao |
| author_facet | Fuzhong Yang Xiangfei Hong Jing Tao Yupeng Chen Yanbo Zhang Hua Xiao |
| author_sort | Fuzhong Yang |
| collection | DOAJ |
| description | Abstract Objective This study aimed to investigate the differences in the relationship between hair cortisol concentration (HCC) and psychosocial stress, social support, clinical features, clinical course, and outcome in schizophrenia and bipolar disorder. Methods A total of 109 schizophrenia patients, 93 bipolar disorder patients and 86 healthy controls between 18 and 60 years old were enrolled in the study. Linear regression and factor analysis were employed to examine and compare the relationship between HCC and childhood trauma, the number of stressful life events, the amount of social support in the three months before the hair cortisol assessment, clinical fearures, clinical course, and outcome in schizophrenia and bipolar disorder. Results HCC is significantly associated with clinical syndromes, including depression–anxiety factor of Positive and Negative Syndrome Scale in schizophrenia patients, and thought disorder in bipolar disorder patients. However, HCC is positively related to social support and personality traits only in schizophrenia patients but not in bipolar disorder patients. Factor analysis indicates schizophrenia and bipolar disorder share a very similar but somewhat different structure in terms of HCC, psychosocial stress, social support, clinical features, clinical course, and outcome. Conclusion Findings support that schizophrenia and bipolar disoder have a significant overlap in both clinical characteristics and enviromental risk factors. Aberrant HCC contributes to the complexity of clinical characteristics mainly in schizophrenia. |
| first_indexed | 2024-03-12T17:36:51Z |
| format | Article |
| id | doaj.art-8bcec8280c4b4dfd960f3656c727fb0c |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:51Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-8bcec8280c4b4dfd960f3656c727fb0c2023-08-04T10:55:54ZengWileyBrain and Behavior2162-32792021-12-011112n/an/a10.1002/brb3.2412Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorderFuzhong Yang0Xiangfei Hong1Jing Tao2Yupeng Chen3Yanbo Zhang4Hua Xiao5Shanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai ChinaShanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai ChinaShanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai ChinaShanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Psychiatry Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta CanadaState Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Sciences School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai ChinaAbstract Objective This study aimed to investigate the differences in the relationship between hair cortisol concentration (HCC) and psychosocial stress, social support, clinical features, clinical course, and outcome in schizophrenia and bipolar disorder. Methods A total of 109 schizophrenia patients, 93 bipolar disorder patients and 86 healthy controls between 18 and 60 years old were enrolled in the study. Linear regression and factor analysis were employed to examine and compare the relationship between HCC and childhood trauma, the number of stressful life events, the amount of social support in the three months before the hair cortisol assessment, clinical fearures, clinical course, and outcome in schizophrenia and bipolar disorder. Results HCC is significantly associated with clinical syndromes, including depression–anxiety factor of Positive and Negative Syndrome Scale in schizophrenia patients, and thought disorder in bipolar disorder patients. However, HCC is positively related to social support and personality traits only in schizophrenia patients but not in bipolar disorder patients. Factor analysis indicates schizophrenia and bipolar disorder share a very similar but somewhat different structure in terms of HCC, psychosocial stress, social support, clinical features, clinical course, and outcome. Conclusion Findings support that schizophrenia and bipolar disoder have a significant overlap in both clinical characteristics and enviromental risk factors. Aberrant HCC contributes to the complexity of clinical characteristics mainly in schizophrenia.https://doi.org/10.1002/brb3.2412bipolar disorderchildhood traumahair cortisol concentrationschizophreniasocial supportstressful life events |
| spellingShingle | Fuzhong Yang Xiangfei Hong Jing Tao Yupeng Chen Yanbo Zhang Hua Xiao Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder Brain and Behavior bipolar disorder childhood trauma hair cortisol concentration schizophrenia social support stressful life events |
| title | Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder |
| title_full | Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder |
| title_fullStr | Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder |
| title_full_unstemmed | Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder |
| title_short | Hair cortisol, social support, personality traits, and clinical course: differences in schizophrenia and bipolar disorder |
| title_sort | hair cortisol social support personality traits and clinical course differences in schizophrenia and bipolar disorder |
| topic | bipolar disorder childhood trauma hair cortisol concentration schizophrenia social support stressful life events |
| url | https://doi.org/10.1002/brb3.2412 |
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