Current knowledge of the implication of lipid mediators in psoriasis
The skin is an organ involved in several biological processes essential to the proper functioning of the organism. One of these essential biological functions of the skin is its barrier function, mediated notably by the lipids of the stratum corneum, and which prevents both penetration from external...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.961107/full |
| _version_ | 1811283378407735296 |
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| author | Mélissa Simard Mélissa Simard Sophie Morin Sophie Morin Zainab Ridha Roxane Pouliot Roxane Pouliot |
| author_facet | Mélissa Simard Mélissa Simard Sophie Morin Sophie Morin Zainab Ridha Roxane Pouliot Roxane Pouliot |
| author_sort | Mélissa Simard |
| collection | DOAJ |
| description | The skin is an organ involved in several biological processes essential to the proper functioning of the organism. One of these essential biological functions of the skin is its barrier function, mediated notably by the lipids of the stratum corneum, and which prevents both penetration from external aggression, and transepidermal water loss. Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFAs) constitute a complex bioactive lipid network greatly involved in skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs have well-documented anti- and pro-inflammatory properties and are recognized as playing numerous and complex roles in the behavior of diverse skin diseases, including psoriasis. Psoriasis is an inflammatory autoimmune disease with many comorbidities and is associated with enhanced levels of pro-inflammatory lipid mediators. Studies have shown that a high intake of n-3 PUFAs can influence the development and progression of psoriasis, mainly by reducing the severity and frequency of psoriatic plaques. Herein, we provide an overview of the differential effects of n-3 and n-6 PUFA lipid mediators, including prostanoids, hydroxy-fatty acids, leukotrienes, specialized pro-resolving mediators, N-acylethanolamines, monoacylglycerols and endocannabinoids. This review summarizes current findings on lipid mediators playing a role in the skin and their potential as therapeutic targets for psoriatic patients. |
| first_indexed | 2024-04-13T02:10:31Z |
| format | Article |
| id | doaj.art-8bd04fb7b6db4d59b3b961dad00ad626 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T02:10:31Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8bd04fb7b6db4d59b3b961dad00ad6262022-12-22T03:07:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.961107961107Current knowledge of the implication of lipid mediators in psoriasisMélissa Simard0Mélissa Simard1Sophie Morin2Sophie Morin3Zainab Ridha4Roxane Pouliot5Roxane Pouliot6Centre de Recherche en Organogénèse Expérimentale de l’Université Laval/Laboratoire d’Organogénèse EXpérimentale (LOEX), Axe Médecine Régénératrice, Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, CanadaFaculté de Pharmacie, Université Laval, Québec, QC, CanadaCentre de Recherche en Organogénèse Expérimentale de l’Université Laval/Laboratoire d’Organogénèse EXpérimentale (LOEX), Axe Médecine Régénératrice, Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, CanadaFaculté de Pharmacie, Université Laval, Québec, QC, CanadaCentre de Recherche en Organogénèse Expérimentale de l’Université Laval/Laboratoire d’Organogénèse EXpérimentale (LOEX), Axe Médecine Régénératrice, Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, CanadaCentre de Recherche en Organogénèse Expérimentale de l’Université Laval/Laboratoire d’Organogénèse EXpérimentale (LOEX), Axe Médecine Régénératrice, Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, CanadaFaculté de Pharmacie, Université Laval, Québec, QC, CanadaThe skin is an organ involved in several biological processes essential to the proper functioning of the organism. One of these essential biological functions of the skin is its barrier function, mediated notably by the lipids of the stratum corneum, and which prevents both penetration from external aggression, and transepidermal water loss. Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFAs) constitute a complex bioactive lipid network greatly involved in skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs have well-documented anti- and pro-inflammatory properties and are recognized as playing numerous and complex roles in the behavior of diverse skin diseases, including psoriasis. Psoriasis is an inflammatory autoimmune disease with many comorbidities and is associated with enhanced levels of pro-inflammatory lipid mediators. Studies have shown that a high intake of n-3 PUFAs can influence the development and progression of psoriasis, mainly by reducing the severity and frequency of psoriatic plaques. Herein, we provide an overview of the differential effects of n-3 and n-6 PUFA lipid mediators, including prostanoids, hydroxy-fatty acids, leukotrienes, specialized pro-resolving mediators, N-acylethanolamines, monoacylglycerols and endocannabinoids. This review summarizes current findings on lipid mediators playing a role in the skin and their potential as therapeutic targets for psoriatic patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.961107/fullpsoriasislipid mediatorskinpolyunsaturated fatty acidsinflammation |
| spellingShingle | Mélissa Simard Mélissa Simard Sophie Morin Sophie Morin Zainab Ridha Roxane Pouliot Roxane Pouliot Current knowledge of the implication of lipid mediators in psoriasis Frontiers in Immunology psoriasis lipid mediator skin polyunsaturated fatty acids inflammation |
| title | Current knowledge of the implication of lipid mediators in psoriasis |
| title_full | Current knowledge of the implication of lipid mediators in psoriasis |
| title_fullStr | Current knowledge of the implication of lipid mediators in psoriasis |
| title_full_unstemmed | Current knowledge of the implication of lipid mediators in psoriasis |
| title_short | Current knowledge of the implication of lipid mediators in psoriasis |
| title_sort | current knowledge of the implication of lipid mediators in psoriasis |
| topic | psoriasis lipid mediator skin polyunsaturated fatty acids inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.961107/full |
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