Myocardial fibrosis in congenital heart disease
Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.965204/full |
| _version_ | 1811307712599818240 |
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| author | Blanca Gordon Víctor González-Fernández Laura Dos-Subirà |
| author_facet | Blanca Gordon Víctor González-Fernández Laura Dos-Subirà |
| author_sort | Blanca Gordon |
| collection | DOAJ |
| description | Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction since it distorts the normal architecture of the myocardium and impairs the biological function and properties of the interstitium. This review summarizes current knowledge on the mechanisms and detrimental consequences of myocardial fibrosis in heart failure and arrhythmias, discusses the usefulness of available imaging techniques and circulating biomarkers to assess this entity and reviews the current body of evidence regarding myocardial fibrosis in the different subsets of congenital heart diseases with implications in research and treatment. |
| first_indexed | 2024-04-13T09:09:14Z |
| format | Article |
| id | doaj.art-8bd0c06a527142a491022097591d4ae9 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T09:09:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-8bd0c06a527142a491022097591d4ae92022-12-22T02:52:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-11-011010.3389/fped.2022.965204965204Myocardial fibrosis in congenital heart diseaseBlanca GordonVíctor González-FernándezLaura Dos-SubiràMyocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction since it distorts the normal architecture of the myocardium and impairs the biological function and properties of the interstitium. This review summarizes current knowledge on the mechanisms and detrimental consequences of myocardial fibrosis in heart failure and arrhythmias, discusses the usefulness of available imaging techniques and circulating biomarkers to assess this entity and reviews the current body of evidence regarding myocardial fibrosis in the different subsets of congenital heart diseases with implications in research and treatment.https://www.frontiersin.org/articles/10.3389/fped.2022.965204/fullmyocardial fibrosisfibrosiscongenital heart diseasecardiac magnetic resonance (CMR)collagen biomarkerstetralogy of Fallot |
| spellingShingle | Blanca Gordon Víctor González-Fernández Laura Dos-Subirà Myocardial fibrosis in congenital heart disease Frontiers in Pediatrics myocardial fibrosis fibrosis congenital heart disease cardiac magnetic resonance (CMR) collagen biomarkers tetralogy of Fallot |
| title | Myocardial fibrosis in congenital heart disease |
| title_full | Myocardial fibrosis in congenital heart disease |
| title_fullStr | Myocardial fibrosis in congenital heart disease |
| title_full_unstemmed | Myocardial fibrosis in congenital heart disease |
| title_short | Myocardial fibrosis in congenital heart disease |
| title_sort | myocardial fibrosis in congenital heart disease |
| topic | myocardial fibrosis fibrosis congenital heart disease cardiac magnetic resonance (CMR) collagen biomarkers tetralogy of Fallot |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.965204/full |
| work_keys_str_mv | AT blancagordon myocardialfibrosisincongenitalheartdisease AT victorgonzalezfernandez myocardialfibrosisincongenitalheartdisease AT lauradossubira myocardialfibrosisincongenitalheartdisease |