Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears
Background: To determine the frequency of abnormal cytological findings in pap smears of women in a local population in Pakistan. Methods: In this observational study conventional PAP smear was collected, from squamocolumnar junction, using an Ayer’s spatula in clockwise direction for 3600 after exp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Rawalpindi Medical University
2018-03-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/854 |
| _version_ | 1818531119570616320 |
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| author | Ghazala Mudassir Mariam Abid Hania Naveed |
| author_facet | Ghazala Mudassir Mariam Abid Hania Naveed |
| author_sort | Ghazala Mudassir |
| collection | DOAJ |
| description | Background: To determine the frequency of
abnormal cytological findings in pap smears of
women in a local population in Pakistan.
Methods: In this observational study conventional
PAP smear was collected, from squamocolumnar
junction, using an Ayer’s spatula in clockwise
direction for 3600 after exposing the cervix by a
Cusco speculum. The endocervical smears were
made by rotating the endocervical brush. The
samples collected were transferred to glass slide and
then slides were fixed in 95% ethyl alcohol. The
slides were then sent to pathology laboratory for
histopathological examination . The adequacy and
reporting of pap smears was based on 2001 Bethesda
system.
Results: Majority of the patients in the
reproductive age group (18- 38 years). Most of the
patients (49.6%) had no cervical complaint and they
underwent the procedure for screening. In
symptomatic patients common presenting
complaints were cervicitis (17.1%) and vaginal
discharge (11.3%).Out of the total 1984 pap smears,
99.1% were negative for intraepithelial lesion or
malignancy. The precursor neoplastic lesions were
observed in 0.8%, which included Atypical
Squamous Cells of Uncertain Significance (ASCUS)
(0.6%), Atypical Glandular Cells of Uncertain
Significance (AGUS) (0.2%) and High Grade
Squamous Intraepithelial Lesion (HSIL)(0.1%).
ASCUS was seen mostly in young age group that is
18- 38 years while HSIL and AGC were identified in
patients more than 50 years of age. Non-specific
inflammatory pattern was seen in 17.6%. Atrophic
pattern was observed in 2.5% smears.
Conclusion- A significant number of abnormal
pap smears were negative for intraepithelial lesion
or malignancy.Epithelial cell abnormalities, though
less prevalent were also seen. |
| first_indexed | 2024-12-11T17:28:19Z |
| format | Article |
| id | doaj.art-8bd296783b794ea59d026ae43f9fef0d |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T17:28:19Z |
| publishDate | 2018-03-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-8bd296783b794ea59d026ae43f9fef0d2022-12-22T00:56:55ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702018-03-01221Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) SmearsGhazala Mudassir0Mariam Abid1Hania Naveed2Department of Pathology, Shifa College of Medicine, Shifa Tameer-e Millat University, Islamabad, PakistanDepartment of Pathology, Shifa College of Medicine, Shifa Tameer-e Millat University, Islamabad, PakistanDepartment of Pathology, Shifa College of Medicine, Shifa Tameer-e Millat University, Islamabad, PakistanBackground: To determine the frequency of abnormal cytological findings in pap smears of women in a local population in Pakistan. Methods: In this observational study conventional PAP smear was collected, from squamocolumnar junction, using an Ayer’s spatula in clockwise direction for 3600 after exposing the cervix by a Cusco speculum. The endocervical smears were made by rotating the endocervical brush. The samples collected were transferred to glass slide and then slides were fixed in 95% ethyl alcohol. The slides were then sent to pathology laboratory for histopathological examination . The adequacy and reporting of pap smears was based on 2001 Bethesda system. Results: Majority of the patients in the reproductive age group (18- 38 years). Most of the patients (49.6%) had no cervical complaint and they underwent the procedure for screening. In symptomatic patients common presenting complaints were cervicitis (17.1%) and vaginal discharge (11.3%).Out of the total 1984 pap smears, 99.1% were negative for intraepithelial lesion or malignancy. The precursor neoplastic lesions were observed in 0.8%, which included Atypical Squamous Cells of Uncertain Significance (ASCUS) (0.6%), Atypical Glandular Cells of Uncertain Significance (AGUS) (0.2%) and High Grade Squamous Intraepithelial Lesion (HSIL)(0.1%). ASCUS was seen mostly in young age group that is 18- 38 years while HSIL and AGC were identified in patients more than 50 years of age. Non-specific inflammatory pattern was seen in 17.6%. Atrophic pattern was observed in 2.5% smears. Conclusion- A significant number of abnormal pap smears were negative for intraepithelial lesion or malignancy.Epithelial cell abnormalities, though less prevalent were also seen.https://www.journalrmc.com/index.php/JRMC/article/view/854Pap smearCervical cancerIntraepithelial lesionMalignancy |
| spellingShingle | Ghazala Mudassir Mariam Abid Hania Naveed Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears Journal of Rawalpindi Medical College Pap smear Cervical cancer Intraepithelial lesion Malignancy |
| title | Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears |
| title_full | Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears |
| title_fullStr | Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears |
| title_full_unstemmed | Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears |
| title_short | Spectrum of Abnormal Cervical Cytology in Papanicolaou (PAP) Smears |
| title_sort | spectrum of abnormal cervical cytology in papanicolaou pap smears |
| topic | Pap smear Cervical cancer Intraepithelial lesion Malignancy |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/854 |
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