A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze
Abstract Background Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff’s Encephalitis (BBE) overlapping class...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1258-x |
| _version_ | 1819056859877736448 |
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| author | Jingzhe Han Yanan Xie Haiyan Yan Yuecheng Cao HongmeiWang Duanhua Cao |
| author_facet | Jingzhe Han Yanan Xie Haiyan Yan Yuecheng Cao HongmeiWang Duanhua Cao |
| author_sort | Jingzhe Han |
| collection | DOAJ |
| description | Abstract Background Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff’s Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (GBS) after aortic valve replacement, accompanied by an excessive PPG in the course of diagnosis and treatment, this was indeed rarely. Case presentation A 55-year-old male patient was admitted to our hospital with intermittent chest tightness for 3 months, and his condition has worsened in the past 10 days. Aortic valve replacement was performed because of the existence of the moderate and severe stenosis of aortic valve. Horizontal movement of the eyeball was involuntarily slow. The eyeball hovered and returned from one side to the other horizontally for 3–4 s per cycle. In combination with the patient’s typical clinical and laboratory tests, the final diagnosis was anti GQ1b antibody syndrome BBE combined with GBS, accompanied by saccadic ping pong gaze. Intravenous immunoglobulin (0.4 g/kg) was given for immunomodulation, methylprednisolone (1000 mg) therapy and symptomatic treatment were performed in the patient. Conclusions The patients were discharged from hospital on the thirtieth day because of economic reasons. After 6 months of follow up, the patients left behind a lack of fluency in speech and limb mobility, but the basic life can be taken care of by himself. |
| first_indexed | 2024-12-21T13:30:07Z |
| format | Article |
| id | doaj.art-8bd39f3dc9f24c87b88ad2bed104c429 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-21T13:30:07Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-8bd39f3dc9f24c87b88ad2bed104c4292022-12-21T19:02:19ZengBMCBMC Neurology1471-23772019-02-011911410.1186/s12883-019-1258-xA case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gazeJingzhe Han0Yanan Xie1Haiyan Yan2Yuecheng Cao3HongmeiWang4Duanhua Cao5Department of Neurology, Harrison International Peace HospitalDepartment of Angiocardiopathy, The Second Hospital of Hebei Medical UniversityDepartment of Neurology, Harrison International Peace HospitalDepartment of Cardiac surgery, Harrison International Peace HospitalDepartment of Neurology, Harrison International Peace HospitalDepartment of Neurology, Harrison International Peace HospitalAbstract Background Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff’s Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (GBS) after aortic valve replacement, accompanied by an excessive PPG in the course of diagnosis and treatment, this was indeed rarely. Case presentation A 55-year-old male patient was admitted to our hospital with intermittent chest tightness for 3 months, and his condition has worsened in the past 10 days. Aortic valve replacement was performed because of the existence of the moderate and severe stenosis of aortic valve. Horizontal movement of the eyeball was involuntarily slow. The eyeball hovered and returned from one side to the other horizontally for 3–4 s per cycle. In combination with the patient’s typical clinical and laboratory tests, the final diagnosis was anti GQ1b antibody syndrome BBE combined with GBS, accompanied by saccadic ping pong gaze. Intravenous immunoglobulin (0.4 g/kg) was given for immunomodulation, methylprednisolone (1000 mg) therapy and symptomatic treatment were performed in the patient. Conclusions The patients were discharged from hospital on the thirtieth day because of economic reasons. After 6 months of follow up, the patients left behind a lack of fluency in speech and limb mobility, but the basic life can be taken care of by himself.http://link.springer.com/article/10.1186/s12883-019-1258-xPeriodic alternating ping-pong gazePPGAnti GQ1b antibody syndromeBBE |
| spellingShingle | Jingzhe Han Yanan Xie Haiyan Yan Yuecheng Cao HongmeiWang Duanhua Cao A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze BMC Neurology Periodic alternating ping-pong gaze PPG Anti GQ1b antibody syndrome BBE |
| title | A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze |
| title_full | A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze |
| title_fullStr | A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze |
| title_full_unstemmed | A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze |
| title_short | A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze |
| title_sort | case of surgically associated anti gq1b antibody syndrome accompanied by saccadic ping pong gaze |
| topic | Periodic alternating ping-pong gaze PPG Anti GQ1b antibody syndrome BBE |
| url | http://link.springer.com/article/10.1186/s12883-019-1258-x |
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