Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers
The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-07-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471300291X |
| _version_ | 1819028685401882624 |
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| author | Henry Garcia Jeffrey C. Miecznikowski Alfiya Safina Mairead Commane Anja Ruusulehto Sami Kilpinen Robert W. Leach Kristopher Attwood Yan Li Seamus Degan Angela R. Omilian Olga Guryanova Olympia Papantonopoulou Jianmin Wang Michael Buck Song Liu Carl Morrison Katerina V. Gurova |
| author_facet | Henry Garcia Jeffrey C. Miecznikowski Alfiya Safina Mairead Commane Anja Ruusulehto Sami Kilpinen Robert W. Leach Kristopher Attwood Yan Li Seamus Degan Angela R. Omilian Olga Guryanova Olympia Papantonopoulou Jianmin Wang Michael Buck Song Liu Carl Morrison Katerina V. Gurova |
| author_sort | Henry Garcia |
| collection | DOAJ |
| description | The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compounds and is not expressed in normal cells of adult mammalian tissues, except for undifferentiated and stem-like cells. Here, we show that FACT expression is strongly associated with poorly differentiated aggressive cancers with low overall survival. In addition, FACT was found to be upregulated during in vitro transformation and to be necessary, but not sufficient, for driving transformation. FACT also promoted survival and growth of established tumor cells. Genome-wide mapping of chromatin-bound FACT indicated that FACT’s role in cancer most likely involves selective chromatin remodeling of genes that stimulate proliferation, inhibit cell death and differentiation, and regulate cellular stress responses. |
| first_indexed | 2024-12-21T06:02:18Z |
| format | Article |
| id | doaj.art-8bd40d907b0c415691d9ba1feb1b2b14 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T06:02:18Z |
| publishDate | 2013-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-8bd40d907b0c415691d9ba1feb1b2b142022-12-21T19:13:44ZengElsevierCell Reports2211-12472013-07-014115917310.1016/j.celrep.2013.06.013Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive CancersHenry Garcia0Jeffrey C. Miecznikowski1Alfiya Safina2Mairead Commane3Anja Ruusulehto4Sami Kilpinen5Robert W. Leach6Kristopher Attwood7Yan Li8Seamus Degan9Angela R. Omilian10Olga Guryanova11Olympia Papantonopoulou12Jianmin Wang13Michael Buck14Song Liu15Carl Morrison16Katerina V. Gurova17Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Biostatistics, SUNY Buffalo, Buffalo, NY 14263, USADepartment of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USAMediSapiens, Ltd., Tukholmankatu 8 A, 00290 Helsinki, FinlandMediSapiens, Ltd., Tukholmankatu 8 A, 00290 Helsinki, FinlandCenter for Computational Research, SUNY Buffalo, Buffalo, NY 14263, USADepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USAHuman Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USADepartment of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Biochemistry, SUNY Buffalo, Buffalo, NY 14263, USADepartment of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USAThe facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compounds and is not expressed in normal cells of adult mammalian tissues, except for undifferentiated and stem-like cells. Here, we show that FACT expression is strongly associated with poorly differentiated aggressive cancers with low overall survival. In addition, FACT was found to be upregulated during in vitro transformation and to be necessary, but not sufficient, for driving transformation. FACT also promoted survival and growth of established tumor cells. Genome-wide mapping of chromatin-bound FACT indicated that FACT’s role in cancer most likely involves selective chromatin remodeling of genes that stimulate proliferation, inhibit cell death and differentiation, and regulate cellular stress responses.http://www.sciencedirect.com/science/article/pii/S221112471300291X |
| spellingShingle | Henry Garcia Jeffrey C. Miecznikowski Alfiya Safina Mairead Commane Anja Ruusulehto Sami Kilpinen Robert W. Leach Kristopher Attwood Yan Li Seamus Degan Angela R. Omilian Olga Guryanova Olympia Papantonopoulou Jianmin Wang Michael Buck Song Liu Carl Morrison Katerina V. Gurova Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers Cell Reports |
| title | Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers |
| title_full | Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers |
| title_fullStr | Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers |
| title_full_unstemmed | Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers |
| title_short | Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers |
| title_sort | facilitates chromatin transcription complex is an accelerator of tumor transformation and potential marker and target of aggressive cancers |
| url | http://www.sciencedirect.com/science/article/pii/S221112471300291X |
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