Incorporation of Metabolic Activation in the HPTLC-SOS-Umu-C Bioassay to Detect Low Levels of Genotoxic Chemicals in Food Contact Materials

Incorporation of Metabolic Activation in the HPTLC-SOS-Umu-C Bioassay to Detect Low Levels of Genotoxic Chemicals in Food Contact Materials

The safety evaluation of food contact materials requires excluding mutagenicity and genotoxicity in migrates. Testing the migrates using in vitro bioassays has been proposed to address this challenge. To be fit for that purpose, bioassays must be capable of detecting very low, safety relevant concen...

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Bibliographic Details
Main Authors: Emma Debon, Paul Rogeboz, Hélia Latado, Gertrud E. Morlock, Daniel Meyer, Claudine Cottet-Fontannaz, Gabriele Scholz, Benoît Schilter, Maricel Marin-Kuan
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Toxics
Subjects:
hazard identification
in vitro genotoxicity
planar chromatography coupled with bioassay
food contact material
limit of biological detection
metabolic activation
Online Access:https://www.mdpi.com/2305-6304/10/9/501

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