Anti-gout Potential of Malaysian Medicinal Plants
Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00261/full |
| _version_ | 1818262325976629248 |
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| author | Fazleen I. Abu Bakar Fazleen I. Abu Bakar Mohd F. Abu Bakar Mohd F. Abu Bakar Asmah Rahmat Norazlin Abdullah Siti F. Sabran Siti F. Sabran Susi Endrini |
| author_facet | Fazleen I. Abu Bakar Fazleen I. Abu Bakar Mohd F. Abu Bakar Mohd F. Abu Bakar Asmah Rahmat Norazlin Abdullah Siti F. Sabran Siti F. Sabran Susi Endrini |
| author_sort | Fazleen I. Abu Bakar |
| collection | DOAJ |
| description | Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. |
| first_indexed | 2024-12-12T19:01:20Z |
| format | Article |
| id | doaj.art-8bd65c12bee842b3be4a0af9d9f6fe89 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T19:01:20Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8bd65c12bee842b3be4a0af9d9f6fe892022-12-22T00:15:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-03-01910.3389/fphar.2018.00261315140Anti-gout Potential of Malaysian Medicinal PlantsFazleen I. Abu Bakar0Fazleen I. Abu Bakar1Mohd F. Abu Bakar2Mohd F. Abu Bakar3Asmah Rahmat4Norazlin Abdullah5Siti F. Sabran6Siti F. Sabran7Susi Endrini8Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, Muar, MalaysiaCentre of Research for Sustainable Uses of Natural Resources, Universiti Tun Hussein Onn Malaysia, Parit Raja, MalaysiaFaculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, Muar, MalaysiaCentre of Research for Sustainable Uses of Natural Resources, Universiti Tun Hussein Onn Malaysia, Parit Raja, MalaysiaFaculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, Muar, MalaysiaFaculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, Muar, MalaysiaFaculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, Muar, MalaysiaCentre of Research for Sustainable Uses of Natural Resources, Universiti Tun Hussein Onn Malaysia, Parit Raja, MalaysiaFaculty of Medicine, YARSI University, Jakarta, IndonesiaGout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated.http://journal.frontiersin.org/article/10.3389/fphar.2018.00261/fullxanthine oxidase inhibitionanti-goutphytochemicalMalaysian medicinal plantsin vitroin vivo |
| spellingShingle | Fazleen I. Abu Bakar Fazleen I. Abu Bakar Mohd F. Abu Bakar Mohd F. Abu Bakar Asmah Rahmat Norazlin Abdullah Siti F. Sabran Siti F. Sabran Susi Endrini Anti-gout Potential of Malaysian Medicinal Plants Frontiers in Pharmacology xanthine oxidase inhibition anti-gout phytochemical Malaysian medicinal plants in vitro in vivo |
| title | Anti-gout Potential of Malaysian Medicinal Plants |
| title_full | Anti-gout Potential of Malaysian Medicinal Plants |
| title_fullStr | Anti-gout Potential of Malaysian Medicinal Plants |
| title_full_unstemmed | Anti-gout Potential of Malaysian Medicinal Plants |
| title_short | Anti-gout Potential of Malaysian Medicinal Plants |
| title_sort | anti gout potential of malaysian medicinal plants |
| topic | xanthine oxidase inhibition anti-gout phytochemical Malaysian medicinal plants in vitro in vivo |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00261/full |
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