From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke

From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke

Cigarette smoking causes hypomethylation of the gene Aryl Hydrocarbon Receptor Repressor (<i>AHRR</i>), which regulates detoxification and oxidative stress-responses. We investigated whether <i>AHRR</i> DNA methylation is related to chronic obstructive pulmonary disease (COPD...

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Bibliographic Details
Main Authors: Qing Chen, Kingsley Okechukwu Nwozor, Maarten van den Berge, Dirk-Jan Slebos, Alen Faiz, Marnix R. Jonker, H. Marike Boezen, Irene H. Heijink, Maaike de Vries
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
COPD
cigarette smoking
AHRR
airway epithelial cells
CRISPR/Cas9
proliferation
Online Access:https://www.mdpi.com/2073-4409/11/21/3423

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