Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis

Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis

Abstract Despite advantages of arsenic trioxide (ATO) in oncological practice, its clinical applications have been hampered by severe cardiotoxicity. The general mechanism of ATO‐induced cardiotoxicity has been attributed to its damage to mitochondria, resulting in cardiac remodeling. Honokiol (HKL)...

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Bibliographic Details
Main Authors: An‐Liang Huang, Fan Yang, Ping Cheng, Dian‐ying Liao, Li Zhou, Xing‐Li Ji, Dou‐Dou Peng, Li Zhang, Ting‐Ting Cheng, Li Ma, Xian‐Gen Xia
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Pharmacology Research & Perspectives
Subjects:
apoptosis
arsenic trioxide
cardiac remodeling
Honokiol
ROS
Online Access:https://doi.org/10.1002/prp2.914

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