Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review
T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Animal Nutrition |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405654523001609 |
| _version_ | 1797317462449979392 |
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| author | Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei Liu |
| author_facet | Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei Liu |
| author_sort | Pengju Wang |
| collection | DOAJ |
| description | T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing. Therefore, suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue. Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature, but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized. In this review, we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects. Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option. This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future. |
| first_indexed | 2024-03-08T03:35:23Z |
| format | Article |
| id | doaj.art-8bdc5909ddeb450aba64454eac7b0d25 |
| institution | Directory Open Access Journal |
| issn | 2405-6545 |
| language | English |
| last_indexed | 2024-03-08T03:35:23Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Animal Nutrition |
| spelling | doaj.art-8bdc5909ddeb450aba64454eac7b0d252024-02-10T04:44:47ZengKeAi Communications Co., Ltd.Animal Nutrition2405-65452024-03-0116251266Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative reviewPengju Wang0Lv-hui Sun1Xu Wang2Qinghua Wu3Aimei Liu4Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, ChinaHubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, ChinaNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, ChinaCollege of Life Science, Yangtze University, Jingzhou 434025, ChinaHubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China; Corresponding author.T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals. T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing. Therefore, suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue. Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature, but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized. In this review, we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects. Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option. This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.http://www.sciencedirect.com/science/article/pii/S2405654523001609T-2 toxinOrgan toxicityProtective agentDetoxification mechanism |
| spellingShingle | Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei Liu Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review Animal Nutrition T-2 toxin Organ toxicity Protective agent Detoxification mechanism |
| title | Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review |
| title_full | Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review |
| title_fullStr | Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review |
| title_full_unstemmed | Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review |
| title_short | Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review |
| title_sort | effective protective agents against the organ toxicity of t 2 toxin and corresponding detoxification mechanisms a narrative review |
| topic | T-2 toxin Organ toxicity Protective agent Detoxification mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2405654523001609 |
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