LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION
The primary deficit of IgA is the most common congenital immunodeficiency defined by the values of serum IgA below 0.07 g/l and normal values of IgG and IgM. Most cases are asymptomatic, only 10-15% is manifested by recurrent or persistent sinopulmonary infections, autoimmune diseases, allergies,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2017-06-01
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| Series: | Romanian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2017-Nr.2/RJP_2017_2_EN_Art-07.pdf |
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| author | Monica Alexoae Mihaela Bataneant Ileana Ioniuc Alina Murgu Alice Azoicai Aurica Rugina |
| author_facet | Monica Alexoae Mihaela Bataneant Ileana Ioniuc Alina Murgu Alice Azoicai Aurica Rugina |
| author_sort | Monica Alexoae |
| collection | DOAJ |
| description | The primary deficit of IgA is the most common congenital immunodeficiency defined by the values of serum IgA
below 0.07 g/l and normal values of IgG and IgM. Most cases are asymptomatic, only 10-15% is manifested by
recurrent or persistent sinopulmonary infections, autoimmune diseases, allergies, malignancies. Some cases develop over the time a common variable immunodeficiency. The frequency of anti-IgA antibody justifies the cautiously use of transfusions of blood, plasma or intravenous immunoglobulin. The authors present a case of primary selective IgA deficiency, where the severity of infectious exacerbations appears to be due to the combination of a lack of IgG4, and discuss the possibilities and limits of therapy in light of recent data from the literature. |
| first_indexed | 2024-12-24T03:16:07Z |
| format | Article |
| id | doaj.art-8bdc61876ade4ccf89136fc87b229fd0 |
| institution | Directory Open Access Journal |
| issn | 1454-0398 2069-6175 |
| language | English |
| last_indexed | 2024-12-24T03:16:07Z |
| publishDate | 2017-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Pediatrics |
| spelling | doaj.art-8bdc61876ade4ccf89136fc87b229fd02022-12-21T17:17:37ZengAmaltea Medical Publishing HouseRomanian Journal of Pediatrics1454-03982069-61752017-06-0166212312610.37897/RJP.2017.2.7LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATIONMonica Alexoae0Mihaela Bataneant1Ileana Ioniuc2Alina Murgu3Alice Azoicai4Aurica Rugina5II Pediatric Clinic Pediatrie, “Gr. T. Popa” University of Medicine and Pharmacy, IasiIII Pediatric Clinic, “Victor Babes” University of Medicine and Pharmacy, TimisoaraII Pediatric Clinic Pediatrie, “Gr. T. Popa” University of Medicine and Pharmacy, IasiII Pediatric Clinic Pediatrie, “Gr. T. Popa” University of Medicine and Pharmacy, IasiII Pediatric Clinic Pediatrie, “Gr. T. Popa” University of Medicine and Pharmacy, IasiII Pediatric Clinic Pediatrie, “Gr. T. Popa” University of Medicine and Pharmacy, IasiThe primary deficit of IgA is the most common congenital immunodeficiency defined by the values of serum IgA below 0.07 g/l and normal values of IgG and IgM. Most cases are asymptomatic, only 10-15% is manifested by recurrent or persistent sinopulmonary infections, autoimmune diseases, allergies, malignancies. Some cases develop over the time a common variable immunodeficiency. The frequency of anti-IgA antibody justifies the cautiously use of transfusions of blood, plasma or intravenous immunoglobulin. The authors present a case of primary selective IgA deficiency, where the severity of infectious exacerbations appears to be due to the combination of a lack of IgG4, and discuss the possibilities and limits of therapy in light of recent data from the literature.https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2017-Nr.2/RJP_2017_2_EN_Art-07.pdfprimary selective iga deficiencyigg4 subclass |
| spellingShingle | Monica Alexoae Mihaela Bataneant Ileana Ioniuc Alina Murgu Alice Azoicai Aurica Rugina LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION Romanian Journal of Pediatrics primary selective iga deficiency igg4 subclass |
| title | LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION |
| title_full | LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION |
| title_fullStr | LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION |
| title_full_unstemmed | LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION |
| title_short | LIMITS AND POSSIBILITIES IN A PRIMARY SELECTIVE IgA DEFICIENCY TREATMENT – CASE PRESENTATION |
| title_sort | limits and possibilities in a primary selective iga deficiency treatment case presentation |
| topic | primary selective iga deficiency igg4 subclass |
| url | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2017-Nr.2/RJP_2017_2_EN_Art-07.pdf |
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