Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness
Introduction: Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971219303935 |
| _version_ | 1819105644395888640 |
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| author | Shantanu Prakash Suruchi Shukla Vangala Ramakrishna Hricha Mishra Amit K. Bhagat Amita Jain |
| author_facet | Shantanu Prakash Suruchi Shukla Vangala Ramakrishna Hricha Mishra Amit K. Bhagat Amita Jain |
| author_sort | Shantanu Prakash |
| collection | DOAJ |
| description | Introduction: Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could not be established. Objective: In the present case control study, we aim to investigate the association of PARV4 with SARI. Methods: The Nasal and Throat swab (NS/TS) samples of 241 cases and 146 healthy controls were tested for most common respiratory viruses and PARV4 by real-time PCR. Results: PARV4 was detected in 64(26.55%) SARI cases and only one healthy control (0.68%). PARV4 was the most common viral agent detected in SARI cases. A strong association of PARV4 is seen with severe respiratory illness. Conclusion: Detection of PARV4 in a significantly higher number of SARI cases, in comparison with controls, suggests association of PARV4 with SARI. PARV4 genotype 2 is the only circulating strain detected in our study. Keywords: PARVO 4 virus, Genotype, Severe acute respiratory illness, India |
| first_indexed | 2024-12-22T02:25:31Z |
| format | Article |
| id | doaj.art-8bdcf1f172fb4528a31de85cc08dac73 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-22T02:25:31Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-8bdcf1f172fb4528a31de85cc08dac732022-12-21T18:42:01ZengElsevierInternational Journal of Infectious Diseases1201-97122020-01-01902125Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illnessShantanu Prakash0Suruchi Shukla1Vangala Ramakrishna2Hricha Mishra3Amit K. Bhagat4Amita Jain5Department of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaDepartment of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaDepartment of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaDepartment of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaDepartment of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaCorresponding author.; Department of Microbiology, King Georges Medical University, Lucknow, UP, 226003, IndiaIntroduction: Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could not be established. Objective: In the present case control study, we aim to investigate the association of PARV4 with SARI. Methods: The Nasal and Throat swab (NS/TS) samples of 241 cases and 146 healthy controls were tested for most common respiratory viruses and PARV4 by real-time PCR. Results: PARV4 was detected in 64(26.55%) SARI cases and only one healthy control (0.68%). PARV4 was the most common viral agent detected in SARI cases. A strong association of PARV4 is seen with severe respiratory illness. Conclusion: Detection of PARV4 in a significantly higher number of SARI cases, in comparison with controls, suggests association of PARV4 with SARI. PARV4 genotype 2 is the only circulating strain detected in our study. Keywords: PARVO 4 virus, Genotype, Severe acute respiratory illness, Indiahttp://www.sciencedirect.com/science/article/pii/S1201971219303935 |
| spellingShingle | Shantanu Prakash Suruchi Shukla Vangala Ramakrishna Hricha Mishra Amit K. Bhagat Amita Jain Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness International Journal of Infectious Diseases |
| title | Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness |
| title_full | Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness |
| title_fullStr | Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness |
| title_full_unstemmed | Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness |
| title_short | Human Parvovirus 4: A harmless bystander or a pathogen of severe acute respiratory illness |
| title_sort | human parvovirus 4 a harmless bystander or a pathogen of severe acute respiratory illness |
| url | http://www.sciencedirect.com/science/article/pii/S1201971219303935 |
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