Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications

Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications

There is an urgent need for predictive in vitro models to improve disease modeling and drug target identification and validation, especially for neurological disorders. Cerebral organoids, as alternative methods to in vivo studies, appear now as powerful tools to decipher complex biological processe...

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Bibliographic Details
Main Authors: Héloïse Castiglione, Pierre-Antoine Vigneron, Camille Baquerre, Frank Yates, Jessica Rontard, Thibault Honegger
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
brain organoid-on-chip
predictive human based in vitro models
standardization
reproducibility
neurotoxicity
Online Access:https://www.mdpi.com/1999-4923/14/11/2301

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