Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children
This study aimed to analyse vitamin D-binding protein (Gc-globulin) serum levels in acute liver failure (ALF) in children in relation to disease outcomes and correlations with other known markers used to evaluate the severity of ALF. Our study included 34 children (mean age 4.87 ± 5.30 years) with A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/5/278 |
| _version_ | 1797568817629495296 |
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| author | Alina Grama Lucia Burac Cornel Olimpiu Aldea Bogdan Bulata Dan Delean Gabriel Samasca Carmen Abrudan Claudia Sirbe Tudor Lucian Pop |
| author_facet | Alina Grama Lucia Burac Cornel Olimpiu Aldea Bogdan Bulata Dan Delean Gabriel Samasca Carmen Abrudan Claudia Sirbe Tudor Lucian Pop |
| author_sort | Alina Grama |
| collection | DOAJ |
| description | This study aimed to analyse vitamin D-binding protein (Gc-globulin) serum levels in acute liver failure (ALF) in children in relation to disease outcomes and correlations with other known markers used to evaluate the severity of ALF. Our study included 34 children (mean age 4.87 ± 5.30 years) with ALF of different causes (metabolic, 26.47%; autoimmune, 23.53%; toxic, 20.59%; infection, 17.65%; unknown, 11.76%) and 30 children without any liver injury (mean age 6.11 ± 4.26 years). The outcome was poor in 14 patients (41.18%), including one child with liver transplantation (2.94%). Serum Gc-globulin levels were significantly lower in ALF patients compared to the control group (151.57 ± 171.8 mg/L vs. 498.63 ± 252.50 mg/L; <i>p</i> < 0.000001), with an optimum cut-off of 163.5 mg/L (Area Under the Curve, AUC, 0.8921; sensitivity, 76.50%; specificity, 100%). Levels were also lower in patients with poor outcomes compared to survivors (59.34 ± 33.73 mg/L vs. 216.12 ± 199.69 mg/L; <i>p</i> < 0.0001), with an optimum cut-off 115 mg/L (AUC, 0.7642; sensitivity, 100%; specificity, 50%). Gc-globulin serum levels were variable according to ALF aetiology, i.e., lower in metabolic, infectious, or unknown causes compared to autoimmune and toxic causes. Gc-globulin serum levels were decreased in children with ALF and lower in those with poor outcomes compared with survivors. Gc-globulin serum levels were correlated with other known parameters used to evaluate the severity of ALF and could help to identify patients at high risk for poor outcomes. |
| first_indexed | 2024-03-10T20:02:28Z |
| format | Article |
| id | doaj.art-8be1d9b91e5247b49f074e13674a3588 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:02:28Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8be1d9b91e5247b49f074e13674a35882023-11-19T23:27:02ZengMDPI AGDiagnostics2075-44182020-05-0110527810.3390/diagnostics10050278Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in ChildrenAlina Grama0Lucia Burac1Cornel Olimpiu Aldea2Bogdan Bulata3Dan Delean4Gabriel Samasca5Carmen Abrudan6Claudia Sirbe7Tudor Lucian Pop82nd Paediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400177 Cluj-Napoca, Romania2nd Paediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400177 Cluj-Napoca, RomaniaPaediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, RomaniaPaediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, RomaniaPaediatric Nephrology, Dialysis and Toxicology Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, RomaniaLaboratory of Medical Analysis, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, RomaniaLaboratory of Medical Analysis, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania2nd Paediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400177 Cluj-Napoca, Romania2nd Paediatric Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400177 Cluj-Napoca, RomaniaThis study aimed to analyse vitamin D-binding protein (Gc-globulin) serum levels in acute liver failure (ALF) in children in relation to disease outcomes and correlations with other known markers used to evaluate the severity of ALF. Our study included 34 children (mean age 4.87 ± 5.30 years) with ALF of different causes (metabolic, 26.47%; autoimmune, 23.53%; toxic, 20.59%; infection, 17.65%; unknown, 11.76%) and 30 children without any liver injury (mean age 6.11 ± 4.26 years). The outcome was poor in 14 patients (41.18%), including one child with liver transplantation (2.94%). Serum Gc-globulin levels were significantly lower in ALF patients compared to the control group (151.57 ± 171.8 mg/L vs. 498.63 ± 252.50 mg/L; <i>p</i> < 0.000001), with an optimum cut-off of 163.5 mg/L (Area Under the Curve, AUC, 0.8921; sensitivity, 76.50%; specificity, 100%). Levels were also lower in patients with poor outcomes compared to survivors (59.34 ± 33.73 mg/L vs. 216.12 ± 199.69 mg/L; <i>p</i> < 0.0001), with an optimum cut-off 115 mg/L (AUC, 0.7642; sensitivity, 100%; specificity, 50%). Gc-globulin serum levels were variable according to ALF aetiology, i.e., lower in metabolic, infectious, or unknown causes compared to autoimmune and toxic causes. Gc-globulin serum levels were decreased in children with ALF and lower in those with poor outcomes compared with survivors. Gc-globulin serum levels were correlated with other known parameters used to evaluate the severity of ALF and could help to identify patients at high risk for poor outcomes.https://www.mdpi.com/2075-4418/10/5/278acute liver failurechildrenGc-globulinvitamin D binding proteinprognostic markerliver transplant |
| spellingShingle | Alina Grama Lucia Burac Cornel Olimpiu Aldea Bogdan Bulata Dan Delean Gabriel Samasca Carmen Abrudan Claudia Sirbe Tudor Lucian Pop Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children Diagnostics acute liver failure children Gc-globulin vitamin D binding protein prognostic marker liver transplant |
| title | Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children |
| title_full | Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children |
| title_fullStr | Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children |
| title_full_unstemmed | Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children |
| title_short | Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children |
| title_sort | vitamin d binding protein gc globulin in acute liver failure in children |
| topic | acute liver failure children Gc-globulin vitamin D binding protein prognostic marker liver transplant |
| url | https://www.mdpi.com/2075-4418/10/5/278 |
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