Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review
Abstract Objective The purpose of this study was to evaluate the CT and MRI findings, clinicopathologic features, and differential diagnosis of Sclerosing angiomatoid nodular transformation (SANT). Methods and materials Seven men and seven women with pathological diagnoses of SANT were included in t...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-023-01008-3 |
| _version_ | 1827970233805045760 |
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| author | Ning-Xin Chen Ming-Liang Wang Hai-Xing Wang Meng-Su Zeng |
| author_facet | Ning-Xin Chen Ming-Liang Wang Hai-Xing Wang Meng-Su Zeng |
| author_sort | Ning-Xin Chen |
| collection | DOAJ |
| description | Abstract Objective The purpose of this study was to evaluate the CT and MRI findings, clinicopathologic features, and differential diagnosis of Sclerosing angiomatoid nodular transformation (SANT). Methods and materials Seven men and seven women with pathological diagnoses of SANT were included in this retrospect study. Patients underwent at least one radiological examination before surgery. The number, shape, margin, size, attenuation, signal intensity, homogeneity, and enhancing pattern of the lesion were evaluated by two abdominal radiologists independently. Immunohistochemistry reports were available for 11 patients. The immunoreactivity to the vascular markers CD8, CD31, and CD34 was assessed. Results The 14 SANT patients (7 men, 7 women; mean age, 43.5 years; age range, 24–56 years) presented with a single lesion and showed no specific clinical symptoms. Among 14 patients, 12 patients underwent MR scan, 5 patients underwent CT scan and 3 patients underwent PET-CT. On CT, all 5 lesions showed hypodensity on non-contrast images and spoke-wheel enhancing pattern after contrast administration, and calcification was observed. On T2WI, 10 cases(83.3%)showed hypointensity and 2 cases (16.7%) showed hyperintensity with central hypointensity. On T1WI, 10 cases (83.3%) were isointense and 2 cases (16.7%) were slightly hypointense. 10 cases (83.3%) showed hypointensity on DWI and 2 cases (16.7%) showed slightly hyperintensity on DWI. After contrast administration, all 12 lesions showed progressive enhancement. 18 F-fluorodeoxyglucose (FDG) uptake in the tumor was seen in all three cases that underwent PET-CT. The maximum standardized uptake value (SUVmax) was 4.5, 5.1, and 3.8 respectively. Results Apart from the progressive spoke-wheel enhancing pattern, DWI and ADC findings will add value to the diagnosis of SANT. |
| first_indexed | 2024-04-09T18:50:46Z |
| format | Article |
| id | doaj.art-8be209f07c3444a3bc9539c6041aff7d |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-09T18:50:46Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-8be209f07c3444a3bc9539c6041aff7d2023-04-09T11:29:57ZengBMCBMC Medical Imaging1471-23422023-04-012311810.1186/s12880-023-01008-3Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature reviewNing-Xin Chen0Ming-Liang Wang1Hai-Xing Wang2Meng-Su Zeng3Department of Radiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Radiology, Zhongshan Hospital, Fudan UniversityDepartment of Pathology, Zhongshan Hospital, Fudan UniversityDepartment of Radiology, Zhongshan Hospital, Fudan UniversityAbstract Objective The purpose of this study was to evaluate the CT and MRI findings, clinicopathologic features, and differential diagnosis of Sclerosing angiomatoid nodular transformation (SANT). Methods and materials Seven men and seven women with pathological diagnoses of SANT were included in this retrospect study. Patients underwent at least one radiological examination before surgery. The number, shape, margin, size, attenuation, signal intensity, homogeneity, and enhancing pattern of the lesion were evaluated by two abdominal radiologists independently. Immunohistochemistry reports were available for 11 patients. The immunoreactivity to the vascular markers CD8, CD31, and CD34 was assessed. Results The 14 SANT patients (7 men, 7 women; mean age, 43.5 years; age range, 24–56 years) presented with a single lesion and showed no specific clinical symptoms. Among 14 patients, 12 patients underwent MR scan, 5 patients underwent CT scan and 3 patients underwent PET-CT. On CT, all 5 lesions showed hypodensity on non-contrast images and spoke-wheel enhancing pattern after contrast administration, and calcification was observed. On T2WI, 10 cases(83.3%)showed hypointensity and 2 cases (16.7%) showed hyperintensity with central hypointensity. On T1WI, 10 cases (83.3%) were isointense and 2 cases (16.7%) were slightly hypointense. 10 cases (83.3%) showed hypointensity on DWI and 2 cases (16.7%) showed slightly hyperintensity on DWI. After contrast administration, all 12 lesions showed progressive enhancement. 18 F-fluorodeoxyglucose (FDG) uptake in the tumor was seen in all three cases that underwent PET-CT. The maximum standardized uptake value (SUVmax) was 4.5, 5.1, and 3.8 respectively. Results Apart from the progressive spoke-wheel enhancing pattern, DWI and ADC findings will add value to the diagnosis of SANT.https://doi.org/10.1186/s12880-023-01008-3Sclerosing angiomatoid nodular transformationComputed tomography imaging(CT)Magnetic resonance imaging (MRI) |
| spellingShingle | Ning-Xin Chen Ming-Liang Wang Hai-Xing Wang Meng-Su Zeng Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review BMC Medical Imaging Sclerosing angiomatoid nodular transformation Computed tomography imaging(CT) Magnetic resonance imaging (MRI) |
| title | Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review |
| title_full | Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review |
| title_fullStr | Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review |
| title_full_unstemmed | Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review |
| title_short | Sclerosing angiomatoid nodular transformation of the spleen: multimodality imaging features and literature review |
| title_sort | sclerosing angiomatoid nodular transformation of the spleen multimodality imaging features and literature review |
| topic | Sclerosing angiomatoid nodular transformation Computed tomography imaging(CT) Magnetic resonance imaging (MRI) |
| url | https://doi.org/10.1186/s12880-023-01008-3 |
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