The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis
Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer’s disease, and Parkinson’s disease). This suggests that BDNF may be involved in the pathogenesis of these diseases...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.924155/full |
| _version_ | 1828325535848071168 |
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| author | Shu-Hui Dou Yu Cui Shu-Ming Huang Bo Zhang |
| author_facet | Shu-Hui Dou Yu Cui Shu-Ming Huang Bo Zhang |
| author_sort | Shu-Hui Dou |
| collection | DOAJ |
| description | Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer’s disease, and Parkinson’s disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided. |
| first_indexed | 2024-04-13T19:24:42Z |
| format | Article |
| id | doaj.art-8be50c002f7a4a39b7acbe4d0bc8fdd8 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T19:24:42Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-8be50c002f7a4a39b7acbe4d0bc8fdd82022-12-22T02:33:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-06-011610.3389/fnhum.2022.924155924155The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease PathogenesisShu-Hui Dou0Yu Cui1Shu-Ming Huang2Bo Zhang3Department of Neuroscience, Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Veterinary Medicine, College of Agriculture, Hainan University, Haikou, ChinaDepartment of Neuroscience, Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Neuroscience, Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, ChinaRecent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer’s disease, and Parkinson’s disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.https://www.frontiersin.org/articles/10.3389/fnhum.2022.924155/fullbrain-derived neurotrophic factorTrkBstrokedepressionanxietyneurodegenerative disease |
| spellingShingle | Shu-Hui Dou Yu Cui Shu-Ming Huang Bo Zhang The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis Frontiers in Human Neuroscience brain-derived neurotrophic factor TrkB stroke depression anxiety neurodegenerative disease |
| title | The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis |
| title_full | The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis |
| title_fullStr | The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis |
| title_full_unstemmed | The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis |
| title_short | The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis |
| title_sort | role of brain derived neurotrophic factor signaling in central nervous system disease pathogenesis |
| topic | brain-derived neurotrophic factor TrkB stroke depression anxiety neurodegenerative disease |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.924155/full |
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