Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India
Context: COVID-19 pandemic continues to be a serious threat to humanity even after the last 2.5 years and multiple reported waves. Post-COVID-19 cognitive impairment has a detrimental effect on the quality of life, education, occupation, psychosocial as well as adaptive functioning and independence....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1099;epage=1103;aulast=Khanna |
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| author | Sanat Kumar Khanna Neelu Khanna Manoj Kumar Malav Himanshu Chhagan Bayad Akshay Sood Leena Abraham |
| author_facet | Sanat Kumar Khanna Neelu Khanna Manoj Kumar Malav Himanshu Chhagan Bayad Akshay Sood Leena Abraham |
| author_sort | Sanat Kumar Khanna |
| collection | DOAJ |
| description | Context: COVID-19 pandemic continues to be a serious threat to humanity even after the last 2.5 years and multiple reported waves. Post-COVID-19 cognitive impairment has a detrimental effect on the quality of life, education, occupation, psychosocial as well as adaptive functioning and independence. Aims and Objective: Profiling the cognitive impairment in the mild COVID-19 recovered patients. Settings and Design: Interview-based case-control study. Materials and Methods: This study was conducted at a secondary healthcare center in a hilly region of north India. Group A included mild COVID-19 recovered patients and Group B included local non-COVID healthy individuals. Both groups of participants were interviewed using Montreal Cognitive Assessment (MoCA) to identify global and domain-wise cognitive impairment. Statistics Used: Descriptive statistics were used to analyze the demographic and clinical variables. The Chi-square test was used to evaluate these results and statistical analysis was done using the Statistical Package for Social Sciences (version 23) program. Results: A total of 284 individuals were enrolled in our study, equally split into Groups A (cases) and B (controls). No global cognitive decline was found in any participant. However, 40 cases scored low on MoCA. The decrease in domain-wise cognitive function was statistically significant for visuospatial skill/executive function and attention. Conclusion: Our results have demonstrated that there is domain-wise cognitive impairment associated with mild COVID-19 disease. We recommend lowering the threshold of the MoCA to identify the early cognitive impairment and the inclusion of detailed cognitive assessment in post-COVID-19 follow-ups to initiate early cognitive rehabilitation among these patients. |
| first_indexed | 2024-04-13T05:32:11Z |
| format | Article |
| id | doaj.art-8be78eb7827d409b8ebeeb97a810b3a6 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-13T05:32:11Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-8be78eb7827d409b8ebeeb97a810b3a62022-12-22T03:00:23ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492022-01-012561099110310.4103/aian.aian_543_22Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North IndiaSanat Kumar KhannaNeelu KhannaManoj Kumar MalavHimanshu Chhagan BayadAkshay SoodLeena AbrahamContext: COVID-19 pandemic continues to be a serious threat to humanity even after the last 2.5 years and multiple reported waves. Post-COVID-19 cognitive impairment has a detrimental effect on the quality of life, education, occupation, psychosocial as well as adaptive functioning and independence. Aims and Objective: Profiling the cognitive impairment in the mild COVID-19 recovered patients. Settings and Design: Interview-based case-control study. Materials and Methods: This study was conducted at a secondary healthcare center in a hilly region of north India. Group A included mild COVID-19 recovered patients and Group B included local non-COVID healthy individuals. Both groups of participants were interviewed using Montreal Cognitive Assessment (MoCA) to identify global and domain-wise cognitive impairment. Statistics Used: Descriptive statistics were used to analyze the demographic and clinical variables. The Chi-square test was used to evaluate these results and statistical analysis was done using the Statistical Package for Social Sciences (version 23) program. Results: A total of 284 individuals were enrolled in our study, equally split into Groups A (cases) and B (controls). No global cognitive decline was found in any participant. However, 40 cases scored low on MoCA. The decrease in domain-wise cognitive function was statistically significant for visuospatial skill/executive function and attention. Conclusion: Our results have demonstrated that there is domain-wise cognitive impairment associated with mild COVID-19 disease. We recommend lowering the threshold of the MoCA to identify the early cognitive impairment and the inclusion of detailed cognitive assessment in post-COVID-19 follow-ups to initiate early cognitive rehabilitation among these patients.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1099;epage=1103;aulast=Khannacase-control studycognitive impairmentcovid-19hilly regionmoca |
| spellingShingle | Sanat Kumar Khanna Neelu Khanna Manoj Kumar Malav Himanshu Chhagan Bayad Akshay Sood Leena Abraham Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India Annals of Indian Academy of Neurology case-control study cognitive impairment covid-19 hilly region moca |
| title | Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India |
| title_full | Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India |
| title_fullStr | Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India |
| title_full_unstemmed | Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India |
| title_short | Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India |
| title_sort | profiling cognitive impairment in mild covid 19 patients a case control study at a secondary healthcare centre in the hilly region of north india |
| topic | case-control study cognitive impairment covid-19 hilly region moca |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=6;spage=1099;epage=1103;aulast=Khanna |
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