Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy
The Ce<sub>0.5</sub>Y<sub>0.35</sub>Tb<sub>0.15</sub>F<sub>3</sub> nanoparticles with a CeF<sub>3</sub> hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminesc...
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MDPI AG
2024-01-01
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| author | Alina I. Khusainova Alexey S. Nizamutdinov Nail I. Shamsutdinov Svetlana Kalinichenko Damir I. Safin Marat Gafurov Elena V. Lukinova Sergey Kh. Batygov Sergey V. Kuznetsov Sergey V. Zinchenko Pavel V. Zelenikhin Maksim Pudovkin |
| author_facet | Alina I. Khusainova Alexey S. Nizamutdinov Nail I. Shamsutdinov Svetlana Kalinichenko Damir I. Safin Marat Gafurov Elena V. Lukinova Sergey Kh. Batygov Sergey V. Kuznetsov Sergey V. Zinchenko Pavel V. Zelenikhin Maksim Pudovkin |
| author_sort | Alina I. Khusainova |
| collection | DOAJ |
| description | The Ce<sub>0.5</sub>Y<sub>0.35</sub>Tb<sub>0.15</sub>F<sub>3</sub> nanoparticles with a CeF<sub>3</sub> hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminescence decay curves of the Ce<sub>0.5</sub>Y<sub>0.35</sub>Tb<sub>0.15</sub>F<sub>3</sub> nanoparticles (λ<sub>em</sub> = 541 nm, <sup>5</sup>D<sub>4</sub>–<sup>7</sup>F<sub>5</sub> transition of Tb<sup>3+</sup>) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb<sup>3+</sup> to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was <i>R</i><sub>0</sub> = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%. |
| first_indexed | 2024-03-08T10:43:29Z |
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| id | doaj.art-8be7c28824d54d01a7fdda6c4ec17e6e |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-08T10:43:29Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-8be7c28824d54d01a7fdda6c4ec17e6e2024-01-26T17:26:37ZengMDPI AGMaterials1996-19442024-01-0117231610.3390/ma17020316Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic TherapyAlina I. Khusainova0Alexey S. Nizamutdinov1Nail I. Shamsutdinov2Svetlana Kalinichenko3Damir I. Safin4Marat Gafurov5Elena V. Lukinova6Sergey Kh. Batygov7Sergey V. Kuznetsov8Sergey V. Zinchenko9Pavel V. Zelenikhin10Maksim Pudovkin11Institute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaDepartment of General Chemistry, Belgorod State National Research University, 85 Pobedy Str., 308015 Belgorod, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaInstitute of Physics, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, RussiaThe Ce<sub>0.5</sub>Y<sub>0.35</sub>Tb<sub>0.15</sub>F<sub>3</sub> nanoparticles with a CeF<sub>3</sub> hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminescence decay curves of the Ce<sub>0.5</sub>Y<sub>0.35</sub>Tb<sub>0.15</sub>F<sub>3</sub> nanoparticles (λ<sub>em</sub> = 541 nm, <sup>5</sup>D<sub>4</sub>–<sup>7</sup>F<sub>5</sub> transition of Tb<sup>3+</sup>) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb<sup>3+</sup> to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was <i>R</i><sub>0</sub> = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%.https://www.mdpi.com/1996-1944/17/2/316photodynamic therapycombined photodynamic therapyRadachlorinnanoparticle-photosensitizer conjugates |
| spellingShingle | Alina I. Khusainova Alexey S. Nizamutdinov Nail I. Shamsutdinov Svetlana Kalinichenko Damir I. Safin Marat Gafurov Elena V. Lukinova Sergey Kh. Batygov Sergey V. Kuznetsov Sergey V. Zinchenko Pavel V. Zelenikhin Maksim Pudovkin Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy Materials photodynamic therapy combined photodynamic therapy Radachlorin nanoparticle-photosensitizer conjugates |
| title | Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy |
| title_full | Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy |
| title_fullStr | Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy |
| title_full_unstemmed | Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy |
| title_short | Photo- and X-ray Induced Cytotoxicity of CeF<sub>3</sub>-YF<sub>3</sub>-TbF<sub>3</sub> Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy |
| title_sort | photo and x ray induced cytotoxicity of cef sub 3 sub yf sub 3 sub tbf sub 3 sub nanoparticle polyvinylpyrrolidone radachlorin composites for combined photodynamic therapy |
| topic | photodynamic therapy combined photodynamic therapy Radachlorin nanoparticle-photosensitizer conjugates |
| url | https://www.mdpi.com/1996-1944/17/2/316 |
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