Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis
Abstract Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent. Methods We performed a systematic review and meta-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-022-02529-4 |
| _version_ | 1828161244224290816 |
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| author | Ehsan Alvandi Wilson K. M. Wong Mugdha V. Joglekar Kevin J. Spring Anandwardhan A. Hardikar |
| author_facet | Ehsan Alvandi Wilson K. M. Wong Mugdha V. Joglekar Kevin J. Spring Anandwardhan A. Hardikar |
| author_sort | Ehsan Alvandi |
| collection | DOAJ |
| description | Abstract Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent. Methods We performed a systematic review and meta-analysis to examine the associations of fecal SCFA concentrations to the incidence and risk of CRC. Data extraction through Medline, Embase, and Web of Science was carried out from database conception to June 29, 2022. Predefined inclusion/exclusion criteria led to the selection of 17 case-control and six cross-sectional studies for quality assessment and analyses. Studies were categorized for CRC risk or incidence, and RevMan 5.4 was used to perform the meta-analyses. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model. Studies lacking quantitation were included in qualitative analyses. Results Combined analysis of acetic, propionic, and butyric acid revealed significantly lower concentrations of these SCFAs in individuals with a high-risk of CRC (SMD = 2.02, 95% CI 0.31 to 3.74, P = 0.02). Additionally, CRC incidence was higher in individuals with lower levels of SCFAs (SMD = 0.45, 95% CI 0.19 to 0.72, P = 0.0009), compared to healthy individuals. Qualitative analyses identified 70.4% of studies reporting significantly lower concentrations of fecal acetic, propionic, butyric acid, or total SCFAs in those at higher risk of CRC, while 66.7% reported significantly lower concentrations of fecal acetic and butyric acid in CRC patients compared to healthy controls. Conclusions Overall, lower fecal concentrations of the three major SCFAs are associated with higher risk of CRC and incidence of CRC. |
| first_indexed | 2024-04-12T00:35:23Z |
| format | Article |
| id | doaj.art-8be7df3df1834dacb69f67fd96307822 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-12T00:35:23Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-8be7df3df1834dacb69f67fd963078222022-12-22T03:55:11ZengBMCBMC Medicine1741-70152022-10-0120111110.1186/s12916-022-02529-4Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysisEhsan Alvandi0Wilson K. M. Wong1Mugdha V. Joglekar2Kevin J. Spring3Anandwardhan A. Hardikar4Diabetes and Islet Biology Group, School of Medicine, Western Sydney UniversityDiabetes and Islet Biology Group, School of Medicine, Western Sydney UniversityDiabetes and Islet Biology Group, School of Medicine, Western Sydney UniversityDiabetes and Islet Biology Group, School of Medicine, Western Sydney UniversityDiabetes and Islet Biology Group, School of Medicine, Western Sydney UniversityAbstract Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent. Methods We performed a systematic review and meta-analysis to examine the associations of fecal SCFA concentrations to the incidence and risk of CRC. Data extraction through Medline, Embase, and Web of Science was carried out from database conception to June 29, 2022. Predefined inclusion/exclusion criteria led to the selection of 17 case-control and six cross-sectional studies for quality assessment and analyses. Studies were categorized for CRC risk or incidence, and RevMan 5.4 was used to perform the meta-analyses. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model. Studies lacking quantitation were included in qualitative analyses. Results Combined analysis of acetic, propionic, and butyric acid revealed significantly lower concentrations of these SCFAs in individuals with a high-risk of CRC (SMD = 2.02, 95% CI 0.31 to 3.74, P = 0.02). Additionally, CRC incidence was higher in individuals with lower levels of SCFAs (SMD = 0.45, 95% CI 0.19 to 0.72, P = 0.0009), compared to healthy individuals. Qualitative analyses identified 70.4% of studies reporting significantly lower concentrations of fecal acetic, propionic, butyric acid, or total SCFAs in those at higher risk of CRC, while 66.7% reported significantly lower concentrations of fecal acetic and butyric acid in CRC patients compared to healthy controls. Conclusions Overall, lower fecal concentrations of the three major SCFAs are associated with higher risk of CRC and incidence of CRC.https://doi.org/10.1186/s12916-022-02529-4Colorectal cancerAdenomaShort-chain fatty acidIncidenceRiskMeta-analysis |
| spellingShingle | Ehsan Alvandi Wilson K. M. Wong Mugdha V. Joglekar Kevin J. Spring Anandwardhan A. Hardikar Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis BMC Medicine Colorectal cancer Adenoma Short-chain fatty acid Incidence Risk Meta-analysis |
| title | Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis |
| title_full | Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis |
| title_fullStr | Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis |
| title_short | Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis |
| title_sort | short chain fatty acid concentrations in the incidence and risk stratification of colorectal cancer a systematic review and meta analysis |
| topic | Colorectal cancer Adenoma Short-chain fatty acid Incidence Risk Meta-analysis |
| url | https://doi.org/10.1186/s12916-022-02529-4 |
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