Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease
Abstract Background Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-018-0686-5 |
| _version_ | 1828739750479003648 |
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| author | Kazuma Yagi Takanori Asakura Ho Namkoong Shoji Suzuki Takahiro Asami Satoshi Okamori Tatsuya Kusumoto Yohei Funatsu Hirofumi Kamata Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa |
| author_facet | Kazuma Yagi Takanori Asakura Ho Namkoong Shoji Suzuki Takahiro Asami Satoshi Okamori Tatsuya Kusumoto Yohei Funatsu Hirofumi Kamata Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa |
| author_sort | Kazuma Yagi |
| collection | DOAJ |
| description | Abstract Background Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease. Methods This cross-sectional study included adult patients with pMAC and was conducted at Keio University Hospital. We investigated the relationship of 6MWT parameters with clinical parameters, including pulmonary function, and HRQL, which was assessed using the 36-Item Short Form Health Survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ). Results In total, 103 consecutive patients with pMAC participated in 6MWT (median age, 64 years; 80 women) and completed SF-36 and SGRQ. The six-minute walk distance (6MWD) showed significant negative and positive correlations with all SGRQ domain scores [ρ = (− 0.54)–(− 0.32)] and the physical component summary (PCS) score (ρ = 0.39) in SF-36, respectively; the opposite was observed for the final Borg scale (FBS) score (all SGRQ scores, ρ = 0.34–0.58; PCS score, ρ = − 0.50). The distance-saturation product showed significant negative and positive correlations with all SGRQ scores [ρ = (− 0.29)–(− 0.55)] and the PCS score (ρ = 0.40), respectively. Multivariate analysis revealed that 6MWD and the FBS score were significant predictors of HRQL. Conclusions Our findings suggest that 6MWD and the FBS score are useful parameters for evaluating HRQL in patients with pMAC. Further studies should investigate the impact of 6WMT parameters on disease progression, treatment responses, and prognosis. |
| first_indexed | 2024-04-13T00:27:58Z |
| format | Article |
| id | doaj.art-8be85be3fa8b4878943e781c2a7ccb65 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-13T00:27:58Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-8be85be3fa8b4878943e781c2a7ccb652022-12-22T03:10:33ZengBMCBMC Pulmonary Medicine1471-24662018-07-011811810.1186/s12890-018-0686-5Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex diseaseKazuma Yagi0Takanori Asakura1Ho Namkoong2Shoji Suzuki3Takahiro Asami4Satoshi Okamori5Tatsuya Kusumoto6Yohei Funatsu7Hirofumi Kamata8Tomoyasu Nishimura9Makoto Ishii10Tomoko Betsuyaku11Naoki Hasegawa12Division of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineKeio University Health CenterDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineCenter for Infectious Diseases and Infection Control, Keio University School of MedicineAbstract Background Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease. Methods This cross-sectional study included adult patients with pMAC and was conducted at Keio University Hospital. We investigated the relationship of 6MWT parameters with clinical parameters, including pulmonary function, and HRQL, which was assessed using the 36-Item Short Form Health Survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ). Results In total, 103 consecutive patients with pMAC participated in 6MWT (median age, 64 years; 80 women) and completed SF-36 and SGRQ. The six-minute walk distance (6MWD) showed significant negative and positive correlations with all SGRQ domain scores [ρ = (− 0.54)–(− 0.32)] and the physical component summary (PCS) score (ρ = 0.39) in SF-36, respectively; the opposite was observed for the final Borg scale (FBS) score (all SGRQ scores, ρ = 0.34–0.58; PCS score, ρ = − 0.50). The distance-saturation product showed significant negative and positive correlations with all SGRQ scores [ρ = (− 0.29)–(− 0.55)] and the PCS score (ρ = 0.40), respectively. Multivariate analysis revealed that 6MWD and the FBS score were significant predictors of HRQL. Conclusions Our findings suggest that 6MWD and the FBS score are useful parameters for evaluating HRQL in patients with pMAC. Further studies should investigate the impact of 6WMT parameters on disease progression, treatment responses, and prognosis.http://link.springer.com/article/10.1186/s12890-018-0686-5Nontuberculous mycobacteriaMycobacterium avium complexSix-minute walk testHealth-related quality of life36-item short form health surveySt. George’s respiratory questionnaire |
| spellingShingle | Kazuma Yagi Takanori Asakura Ho Namkoong Shoji Suzuki Takahiro Asami Satoshi Okamori Tatsuya Kusumoto Yohei Funatsu Hirofumi Kamata Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease BMC Pulmonary Medicine Nontuberculous mycobacteria Mycobacterium avium complex Six-minute walk test Health-related quality of life 36-item short form health survey St. George’s respiratory questionnaire |
| title | Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease |
| title_full | Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease |
| title_fullStr | Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease |
| title_full_unstemmed | Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease |
| title_short | Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease |
| title_sort | association between six minute walk test parameters and the health related quality of life in patients with pulmonary mycobacterium avium complex disease |
| topic | Nontuberculous mycobacteria Mycobacterium avium complex Six-minute walk test Health-related quality of life 36-item short form health survey St. George’s respiratory questionnaire |
| url | http://link.springer.com/article/10.1186/s12890-018-0686-5 |
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