Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study
Fahidah AlEnzi,1 Bashaer Alqahtani,2 Esam H Alhamad,3 Maha Daghestani,2 Yusra Tashkandy,4 Nashwa Othman,5 Khalid Alshahrani,6 Muthurajan P Paramasivam,3 Rabih Halwani,7 Mohammed A Omair8 1Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | Open Access Rheumatology: Research and Reviews |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fatigue-in-saudi-patients-with-primary-sjoumlgrenrsquos-syndrome-and-i-peer-reviewed-article-OARRR |
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| author | AlEnzi F Alqahtani B Alhamad EH Daghestani M Tashkandy Y Othman N Alshahrani K Paramasivam MP Halwani R Omair MA |
| author_facet | AlEnzi F Alqahtani B Alhamad EH Daghestani M Tashkandy Y Othman N Alshahrani K Paramasivam MP Halwani R Omair MA |
| author_sort | AlEnzi F |
| collection | DOAJ |
| description | Fahidah AlEnzi,1 Bashaer Alqahtani,2 Esam H Alhamad,3 Maha Daghestani,2 Yusra Tashkandy,4 Nashwa Othman,5 Khalid Alshahrani,6 Muthurajan P Paramasivam,3 Rabih Halwani,7 Mohammed A Omair8 1Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Pulmonary Division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 4Department of Statistics and Operations Research, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 5Central Laboratory, King Saud University, Riyadh, Saudi Arabia; 6Rheumatology Division, Department of Medicine, Ad Diriyah Hospital, Ministry of Health, Riyadh, Saudi Arabia; 7Department of Clinical Sciences, Sharjah Institute for Medical Research (SIMR), College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 8Rheumatology Division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Fahidah AlEnzi Department of Clinical ScienceCollege of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaEmail fmalenzi@pnu.edu.saBackground: Fatigue is a prevalent symptom affecting primary Sjögren’s syndrome (pSS) patients. The purpose of this study is to determine the prevalence of fatigue in Saudi pSS patients and its correlation with disease features and outcome measures using a validated tool.Methods: This is a cross-sectional study evaluating fatigue in pSS using the Arabic version of the fatigue severity scale (FSS). The EULAR Sjögren’s syndrome disease activity index (ESSDAI) and EULAR Sjögren’s syndrome patient reported index (ESSPRI) were calculated.Results: Forty-one patients met the sample criteria and were involved in the final report. There were predominantly females (78%) with a mean (±SD) age and disease duration of 58.76± 12.7 and 4.6± 2.28 years, respectively. Based on the FSS, 18 (43.9%) patients had a positive test with a mean score of 5.43± 0.76. The mean ESSDAI was 9.95± 7.73, while the mean EESPRI was 5.17± 2.4 with individual component scores were dryness (5.23± 2.62), fatigue (5.4± 2.88), and pain (4.88± 3.31). The FSS had a significant correlation with PGA (r=0.559; p< 0.001), PhGA (r=0.671; p< 0.001), ESSDAI (r=0.402; p=0.01), ESSPRI fatigue component (r=0.0.621; p< 0.001), ESSPRI pain component (r=0.558; p< 0.001), and missed significance for the ESSPRI dryness component (r=0.289; p=0.071). There was no correlation between the total ESSPRI score and presence of fatigue (r=− 0.261; p=0.104) nor the FSS score (r=− 0.136; p=0.409).Conclusion: Fatigue is prevalent in Saudi pSS patients. FSS correlated with ESSDAI and ESSPRI components but not its total score signaling other unmeasured factors contributing to fatigue development.Keywords: fatigue, Sjögren’s syndrome, FSS-Ar, ESSPRI |
| first_indexed | 2024-12-18T04:04:21Z |
| format | Article |
| id | doaj.art-8beac254c8e9422f93a16b937e4d55e3 |
| institution | Directory Open Access Journal |
| issn | 1179-156X |
| language | English |
| last_indexed | 2024-12-18T04:04:21Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Rheumatology: Research and Reviews |
| spelling | doaj.art-8beac254c8e9422f93a16b937e4d55e32022-12-21T21:21:38ZengDove Medical PressOpen Access Rheumatology: Research and Reviews1179-156X2020-12-01Volume 1230330859919Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional StudyAlEnzi FAlqahtani BAlhamad EHDaghestani MTashkandy YOthman NAlshahrani KParamasivam MPHalwani ROmair MAFahidah AlEnzi,1 Bashaer Alqahtani,2 Esam H Alhamad,3 Maha Daghestani,2 Yusra Tashkandy,4 Nashwa Othman,5 Khalid Alshahrani,6 Muthurajan P Paramasivam,3 Rabih Halwani,7 Mohammed A Omair8 1Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Pulmonary Division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 4Department of Statistics and Operations Research, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 5Central Laboratory, King Saud University, Riyadh, Saudi Arabia; 6Rheumatology Division, Department of Medicine, Ad Diriyah Hospital, Ministry of Health, Riyadh, Saudi Arabia; 7Department of Clinical Sciences, Sharjah Institute for Medical Research (SIMR), College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; 8Rheumatology Division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Fahidah AlEnzi Department of Clinical ScienceCollege of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaEmail fmalenzi@pnu.edu.saBackground: Fatigue is a prevalent symptom affecting primary Sjögren’s syndrome (pSS) patients. The purpose of this study is to determine the prevalence of fatigue in Saudi pSS patients and its correlation with disease features and outcome measures using a validated tool.Methods: This is a cross-sectional study evaluating fatigue in pSS using the Arabic version of the fatigue severity scale (FSS). The EULAR Sjögren’s syndrome disease activity index (ESSDAI) and EULAR Sjögren’s syndrome patient reported index (ESSPRI) were calculated.Results: Forty-one patients met the sample criteria and were involved in the final report. There were predominantly females (78%) with a mean (±SD) age and disease duration of 58.76± 12.7 and 4.6± 2.28 years, respectively. Based on the FSS, 18 (43.9%) patients had a positive test with a mean score of 5.43± 0.76. The mean ESSDAI was 9.95± 7.73, while the mean EESPRI was 5.17± 2.4 with individual component scores were dryness (5.23± 2.62), fatigue (5.4± 2.88), and pain (4.88± 3.31). The FSS had a significant correlation with PGA (r=0.559; p< 0.001), PhGA (r=0.671; p< 0.001), ESSDAI (r=0.402; p=0.01), ESSPRI fatigue component (r=0.0.621; p< 0.001), ESSPRI pain component (r=0.558; p< 0.001), and missed significance for the ESSPRI dryness component (r=0.289; p=0.071). There was no correlation between the total ESSPRI score and presence of fatigue (r=− 0.261; p=0.104) nor the FSS score (r=− 0.136; p=0.409).Conclusion: Fatigue is prevalent in Saudi pSS patients. FSS correlated with ESSDAI and ESSPRI components but not its total score signaling other unmeasured factors contributing to fatigue development.Keywords: fatigue, Sjögren’s syndrome, FSS-Ar, ESSPRIhttps://www.dovepress.com/fatigue-in-saudi-patients-with-primary-sjoumlgrenrsquos-syndrome-and-i-peer-reviewed-article-OARRRfatiguesjögren’s syndromefss-aresspri |
| spellingShingle | AlEnzi F Alqahtani B Alhamad EH Daghestani M Tashkandy Y Othman N Alshahrani K Paramasivam MP Halwani R Omair MA Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study Open Access Rheumatology: Research and Reviews fatigue sjögren’s syndrome fss-ar esspri |
| title | Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study |
| title_full | Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study |
| title_fullStr | Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study |
| title_full_unstemmed | Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study |
| title_short | Fatigue in Saudi Patients with Primary Sjögren’s Syndrome and Its Correlation with Disease Characteristics and Outcome Measures: A Cross-Sectional Study |
| title_sort | fatigue in saudi patients with primary sj ouml gren rsquo s syndrome and its correlation with disease characteristics and outcome measures a cross sectional study |
| topic | fatigue sjögren’s syndrome fss-ar esspri |
| url | https://www.dovepress.com/fatigue-in-saudi-patients-with-primary-sjoumlgrenrsquos-syndrome-and-i-peer-reviewed-article-OARRR |
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